Risk of Dental Discoloration and Enamel Dysplasia in Children Exposed to Tetracycline and Its Derivatives.

Autor:	Kim SJ; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea., Kim EH; Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea., Lee M; Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea., Baek JY; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea., Lee JY; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea., Shin JH; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea., Lim SM; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea., Kim MY; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.; Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, Korea., Jung I; Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea., Ahn JG; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.; Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, Korea., Kang CM; Department of Pediatric Dentistry, Yonsei University College of Dentistry, Seoul, Korea., Kang JM; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.; Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, Korea. umi87c@yuhs.ac.
Jazyk:	angličtina
Zdroj:	Yonsei medical journal [Yonsei Med J] 2022 Dec; Vol. 63 (12), pp. 1113-1120.
DOI:	10.3349/ymj.2022.0388
Abstrakt:	Purpose: To examine the risk of dental abnormalities after exposure to tetracycline and its derivatives (TCs) in Korean children. Materials and Methods: Children aged 0-17 years with a claim for prescriptions of TCs between 2002 and 2015 were identified from the Sample Research Database 2.0 of the National Health Insurance Service. Children not exposed to TCs were selected as the control group by matching sex and age (1:4). Cumulative incidence rate and relative risk of dental abnormalities after TCs exposure were investigated. Results: The 10-year cumulative incidence rate in the 0-12 years group was 3.1% [95% confidence interval (CI), 2.3-3.9]. The 10-year cumulative incidence rates were 7.0%, 1.9%, and 1.6% in the 0-7, 8-12, and 13-17 years age groups (95% CI: 4.7-9.3, 1.2-2.6, and 1.3-1.9, respectively). There was no significant difference in the risk of dental abnormalities according to TC exposure among the age groups of 0-7 years [adjusted hazard ratio (aHR)=1.0], 8-12 years (aHR=1.1), and 13-17 years (aHR=1.2). Conclusion: Short-term exposure to TCs does not appear to increase the risk of dental abnormalities in children aged 0-7 and 0-12 years. Restrictions on the use of TCs in children aged 8-12 years, in some countries, may warrant consideration. Competing Interests: The authors have no potential conflicts of interest to disclose. (© Copyright: Yonsei University College of Medicine 2022.)
Databáze:	MEDLINE
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