Tubulin posttranslational modifications modify the atypical spermatozoon centriole.

Autor:	Turner KA; The University of Toledo, Toledo, Ohio, USA., Kluczynski DF; The University of Toledo, Toledo, Ohio, USA., Hefner RJ; The University of Toledo, Toledo, Ohio, USA., Moussa RB; The University of Toledo, Toledo, Ohio, USA., Slogar JN; The University of Toledo, Toledo, Ohio, USA., Thekkethottiyil JB; The University of Toledo, Toledo, Ohio, USA., Prine HD; The University of Toledo, Toledo, Ohio, USA., Crossley ER; The University of Toledo, Toledo, Ohio, USA., Flanagan LJ; The University of Toledo, Toledo, Ohio, USA., LaBoy MM; The University of Toledo, Toledo, Ohio, USA., Moran MB; The University of Toledo, Toledo, Ohio, USA., Boyd TG; The University of Toledo, Toledo, Ohio, USA., Kujawski BA; The University of Toledo, Toledo, Ohio, USA., Ruble K; The University of Toledo, Toledo, Ohio, USA., Pap JM; The University of Toledo, Toledo, Ohio, USA., Jaiswal A; The University of Toledo, Toledo, Ohio, USA., Shah TA; The University of Toledo, Toledo, Ohio, USA., Sindhwani P; The University of Toledo, Toledo, Ohio, USA., Avidor-Reiss T; The University of Toledo, Toledo, Ohio, USA.
Jazyk:	angličtina
Zdroj:	MicroPublication biology [MicroPubl Biol] 2022 Nov 12; Vol. 2022. Date of Electronic Publication: 2022 Nov 12 (Print Publication: 2022).
DOI:	10.17912/micropub.biology.000678
Abstrakt:	Sperm cells are transcriptionally and translationally silent. Therefore, they may use one of the remaining mechanisms to respond to stimuli in their environment, the post-translational modification of their proteins. Here we examined three post-translational modifications, acetylation, glutamylation, and glycylation of the protein tubulin in human and cattle sperm. Tubulin is the monomer that makes up microtubules, and microtubules constitute the core component of both the sperm centrioles and the axoneme. We found that the sperm of both species were labeled by antibodies against acetylated tubulin and glutamylated tubulin. (Copyright: © 2022 by the authors.)
Databáze:	MEDLINE
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