Impairment of Sexual Desire in Treatment-Resistant Depression: Prevalence and Correlates.

Autor:	Gonçalves WDS; Treatment-Resistant Depression Outpatient Clinic, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Sexual Dysfunction Unit, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Corresponding author: Walter dos Santos Gonçalves, MD, MSc, Outpatient Clinic-Institute of Psychiatry-UFRJ, Av., Lassen RDH; Treatment-Resistant Depression Outpatient Clinic, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Sardinha A; Sexual Dysfunction Unit, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Coutinho ESF; Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Baldwin DS; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Nardi AE; Treatment-Resistant Depression Outpatient Clinic, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Appolinario JC; Treatment-Resistant Depression Outpatient Clinic, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Jazyk:	angličtina
Zdroj:	The primary care companion for CNS disorders [Prim Care Companion CNS Disord] 2022 Nov 22; Vol. 24 (6). Date of Electronic Publication: 2022 Nov 22.
DOI:	10.4088/PCC.22m03275
Abstrakt:	Objective: To assess sexual desire in patients with treatment-resistant depression (TRD). Methods: Baseline data were analyzed from an ongoing cohort study at an outpatient clinic specializing in TRD treatment in Brazil. The cohort comprised consecutive patients with the diagnosis of TRD who sought treatment at this center between November 2015 and January 2021. The Hamilton Depression Rating Scale (HDRS) genital symptoms item (item 14) was used as a proxy to assess sexual desire. Results: Sixty-five participants with TRD were included. There was sexual desire impairment in 67.7% of patients. Men (87.5%) were more affected than women (61.2%), and this difference was statistically significant ( P  = .05). Depression severity was associated with greater complaints of this aspect of sexual function ( P  < .01). Conclusions: Participants with TRD had a high prevalence of sexual desire impairment, which was associated with greater depressive symptom severity and male sex. The findings suggest that health care professionals should systematically assess sexual desire in patients with TRD in daily clinical practice. Further longitudinal studies are needed in larger samples using specific instruments for assessing sexual dysfunction and comparing TRD and non-TRD populations. (© Copyright 2022 Physicians Postgraduate Press, Inc.)
Databáze:	MEDLINE
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