Application of 123 I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography.

Autor: Nakajo M; Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan. toyo.nakajo@dolphin.ocn.ne.jp., Horizoe Y; Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan., Kawaji K; Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan., Jinguji M; Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan., Tani A; Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan., Fukukura Y; Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan., Ohishi M; Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan., Yoshiura T; Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
Jazyk: angličtina
Zdroj: Japanese journal of radiology [Jpn J Radiol] 2023 Apr; Vol. 41 (4), pp. 437-448. Date of Electronic Publication: 2022 Nov 28.
DOI: 10.1007/s11604-022-01365-z
Abstrakt: Purpose: This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [ 123 I]-metaiodobenzylguanidine ([ 123 I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma.
Materials and Methods: This study included 18 patients with pheochromocytoma who underwent both planar and [ 123 I]-MIBG single-photon emission computed tomography/computed tomography scans and echocardiography before surgery. Myocardial [ 123 I]-MIBG visibility and SUVmax were compared with echocardiographic parameters related to systolic and diastolic functions. The Mann-Whitney U test, Fisher exact test, or Spearman rank correlation assessed differences or relationships between two quantitative variables.
Results: On visual analysis, 6 patients showed normal myocardial [ 123 I]-MIBG uptake, whereas 12 patients showed decreased myocardial [ 123 I]-MIBG uptake. No patients showed systolic dysfunction. A significant difference was observed in the incidence of diastolic dysfunction between the groups with normal and decreased uptake (p = 0.009), and left ventricular (LV) diastolic dysfunction was observed in 9 (75%) of 12 patients with decreased myocardial uptake. The myocardial SUVmax was significantly lower in 9 patients with LV diastolic dysfunction than in 9 patients with normal cardiac function (1.67 ± 0.37 vs. 3.03 ± 1.38, p = 0.047). Myocardial SUVmax was positively correlated with septal e' (early diastolic velocity of septal mitral annulus) (ρ = 0.51, p = 0.031) and negatively correlated with the septal E/e' ratio (early mitral E-velocity to early diastolic velocity of septal mitral annulus; ρ =  - 0.64, p = 0.004), respectively.
Conclusions: LV diastolic dysfunction was inversely related to myocardial [ 123 I]-MIBG uptake. Myocardial [ 123 I]-MIBG SUVmax may be useful for characterizing cardiac function in patients with pheochromocytoma. Second abstract. The semiquantitative analysis using the myocardial SUVmax in 123 I-MIBG SPECT/CT was found to be potentially useful for characterizing cardiac function in patients with pheochromocytoma.
(© 2022. The Author(s).)
Databáze: MEDLINE
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