Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy.

Autor:	Rajtak A; 1st Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland., Ostrowska-Leśko M; 1st Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland.; Chair and Department of Toxicology, Medical University of Lublin, Lublin, Poland., Żak K; 1st Chair and Department of Oncological Gynaecology and Gynaecology, Student Scientific Association, Medical University of Lublin, Lublin, Poland., Tarkowski R; 1st Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland., Kotarski J; 1st Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland., Okła K; 1st Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland.; Department of Surgery, University of Michigan Rogel Cancer Center, Ann Arbor, MI, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Nov 10; Vol. 13, pp. 1018256. Date of Electronic Publication: 2022 Nov 10 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.1018256
Abstrakt:	Cancer is a disease that induces many local and systemic changes in immunity. The difficult nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a delayed diagnosis and treatment. Despite the enormous progress in immunotherapy, its efficacy remains limited. The heterogeneity of tumors, lack of diagnostic biomarkers, and complex immune landscape are the main challenges in the treatment of ovarian cancer. Integrative approaches that combine the tumor microenvironment - local immunity - together with periphery - systemic immunity - are urgently needed to improve the understanding of the disease and the efficacy of treatment. In fact, multiparametric analyses are poised to improve our understanding of ovarian tumor immunology. We outline an integrative approach including local and systemic immunity in ovarian cancer. Understanding the nature of both localized and systemic immune responses will be crucial to boosting the efficacy of immunotherapies in ovarian cancer patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Rajtak, Ostrowska-Leśko, Żak, Tarkowski, Kotarski and Okła.)
Databáze:	MEDLINE
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