fMRI BOLD and MEG theta power reflect complementary aspects of activity during lexicosemantic decision in adolescents with ASD.

Autor:	Wilkinson M; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United States.; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States., Keehn RJJ; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States., Linke AC; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States., You Y; Spatiotemporal Brain Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA, United States., Gao Y; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United States.; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States., Alemu K; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States., Correas A; Spatiotemporal Brain Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA, United States., Rosen BQ; Spatiotemporal Brain Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA, United States., Kohli JS; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United States.; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States., Wagner L; Spatiotemporal Brain Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA, United States., Sridhar A; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States., Marinkovic K; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United States.; Spatiotemporal Brain Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA, United States.; Radiology Department, University of California at San Diego, CA, United States., Müller RA; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United States.; Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, United States.
Jazyk:	angličtina
Zdroj:	Neuroimage. Reports [Neuroimage Rep] 2022 Dec; Vol. 2 (4). Date of Electronic Publication: 2022 Oct 15.
DOI:	10.1016/j.ynirp.2022.100134
Abstrakt:	Neuroimaging studies of autism spectrum disorder (ASD) have been predominantly unimodal. While many fMRI studies have reported atypical activity patterns for diverse tasks, the MEG literature in ASD remains comparatively small. Our group recently reported atypically increased event-related theta power in individuals with ASD during lexicosemantic processing. The current multimodal study examined the relationship between fMRI BOLD signal and anatomically-constrained MEG (aMEG) theta power. Thirty-three adolescents with ASD and 23 typically developing (TD) peers took part in both fMRI and MEG scans, during which they distinguished between standard words (SW), animal words (AW), and pseudowords (PW). Regions-of-interest (ROIs) were derived based on task effects detected in BOLD signal and aMEG theta power. BOLD signal and theta power were extracted for each ROI and word condition. Compared to TD participants, increased theta power in the ASD group was found across several time windows and regions including left fusiform and inferior frontal, as well as right angular and anterior cingulate gyri, whereas BOLD signal was significantly increased in the ASD group only in right anterior cingulate gyrus. No significant correlations were observed between BOLD signal and theta power. Findings suggest that the common interpretation of increases in BOLD signal and theta power as 'activation' require careful differentiation, as these reflect largely distinct aspects of regional brain activity. Some group differences in dynamic neural processing detected with aMEG that are likely relevant for lexical processing may be obscured by the hemodynamic signal source and low temporal resolution of fMRI. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Databáze:	MEDLINE
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