Outcomes of laboratory-confirmed SARS-CoV-2 infection during resurgence driven by Omicron lineages BA.4 and BA.5 compared with previous waves in the Western Cape Province, South Africa.

Autor:	Davies MA; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; Division of Public Health Medicine, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: mary-ann.davies@uct.ac.za., Morden E; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Division of Public Health Medicine, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa., Rousseau P; National Department of Health, Pretoria, South Africa., Arendse J; Western Cape Government: Health, Cape Town, South Africa., Bam JL; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa., Boloko L; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa., Cloete K; Western Cape Government: Health, Cape Town, South Africa., Cohen C; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Chetty N; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa., Dane P; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa., Heekes A; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa., Hsiao NY; Division of Medical Virology, University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, South Africa., Hunter M; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Division of Public Health Medicine, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa., Hussey H; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Division of Public Health Medicine, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; Metro Health Services, Western Cape Government: Health, Cape Town, South Africa., Jacobs T; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa., Jassat W; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa., Kariem S; Western Cape Government: Health, Cape Town, South Africa., Kassanjee R; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa., Laenen I; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Division of Health Systems and Public Health, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa., Roux SL; Western Cape Government: Health, Cape Town, South Africa; Karl Bremer Hospital, Western Cape Government: Health, Cape Town, South Africa., Lessells R; KwaZulu-Natal Research, Innovation & Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Mahomed H; Metro Health Services, Western Cape Government: Health, Cape Town, South Africa; Division of Health Systems and Public Health, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa., Maughan D; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa., Meintjes G; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa., Mendelson M; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa., Mnguni A; Khayelitsha District Hospital, Western Cape Government: Health, Cape Town, South Africa., Moodley M; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa., Murie K; Western Cape Government: Health, Cape Town, South Africa; Metro Health Services, Western Cape Government: Health, Cape Town, South Africa., Naude J; Mitchells Plain Hospital, Western Cape Government: Health, Cape Town, South Africa., Ntusi NAB; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, Cape Town, South Africa., Paleker M; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Division of Health Systems and Public Health, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa., Parker A; Tygerberg Hospital, Western Cape Government: Health, Cape Town, South Africa; Division of Infectious Diseases, Department of Medicine, Stellenbosch University, Stellenbosch, South Africa; Division of General Medicine, Department of Medicine, Stellenbosch University, Stellenbosch, South Africa., Pienaar D; Rural Health Services, Western Cape Government: Health, Cape Town, South Africa., Preiser W; National Health Laboratory Service, South Africa; Division of Medical Virology, University of Stellenbosch, Stellenbosch, South Africa., Prozesky H; Tygerberg Hospital, Western Cape Government: Health, Cape Town, South Africa; Division of Infectious Diseases, Department of Medicine, Stellenbosch University, Stellenbosch, South Africa., Raubenheimer P; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa., Rossouw L; Western Cape Government: Health, Cape Town, South Africa., Schrueder N; Tygerberg Hospital, Western Cape Government: Health, Cape Town, South Africa; Division of General Medicine, Department of Medicine, Stellenbosch University, Stellenbosch, South Africa., Smith B; Western Cape Government: Health, Cape Town, South Africa; Karl Bremer Hospital, Western Cape Government: Health, Cape Town, South Africa., Smith M; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa., Solomon W; National Department of Health, Pretoria, South Africa., Symons G; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa., Taljaard J; Tygerberg Hospital, Western Cape Government: Health, Cape Town, South Africa; Division of Infectious Diseases, Department of Medicine, Stellenbosch University, Stellenbosch, South Africa., Wasserman S; Groote Schuur Hospital, Western Cape Government: Health, Cape Town, South Africa; Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Wilkinson RJ; The Francis Crick Institute, London, UK; Department of Infectious Diseases, Imperial College London, London, UK; Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Wolmarans M; National Department of Health, Pretoria, South Africa., Wolter N; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; School of Pathology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa., Boulle A; Health Intelligence, Western Cape Government: Health, Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; Division of Public Health Medicine, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2023 Feb; Vol. 127, pp. 63-68. Date of Electronic Publication: 2022 Nov 24.
DOI:	10.1016/j.ijid.2022.11.024
Abstrakt:	Objectives: We aimed to compare the clinical severity of Omicron BA.4/BA.5 infection with BA.1 and earlier variant infections among laboratory-confirmed SARS-CoV-2 cases in the Western Cape, South Africa, using timing of infection to infer the lineage/variant causing infection. Methods: We included public sector patients aged ≥20 years with laboratory-confirmed COVID-19 between May 01-May 21, 2022 (BA.4/BA.5 wave) and equivalent previous wave periods. We compared the risk between waves of (i) death and (ii) severe hospitalization/death (all within 21 days of diagnosis) using Cox regression adjusted for demographics, comorbidities, admission pressure, vaccination, and previous infection. Results: Among 3793 patients from the BA.4/BA.5 wave and 190,836 patients from previous waves, the risk of severe hospitalization/death was similar in the BA.4/BA.5 and BA.1 waves (adjusted hazard ratio [aHR] 1.12; 95% confidence interval [CI] 0.93; 1.34). Both Omicron waves had a lower risk of severe outcomes than previous waves. Previous infection (aHR 0.29, 95% CI 0.24; 0.36) and vaccination (aHR 0.17; 95% CI 0.07; 0.40 for at least three doses vs no vaccine) were protective. Conclusion: Disease severity was similar among diagnosed COVID-19 cases in the BA.4/BA.5 and BA.1 periods in the context of growing immunity against SARS-CoV-2 due to previous infection and vaccination, both of which were strongly protective. (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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