Design, synthesis and anticancer activity of 5-((2-(4-bromo/chloro benzoyl) benzofuran-5-yl) methyl)-2-((1-(substituted)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde analogues.

Autor: Vishnu T; Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India.; Department of Sciences and Humanities, Matrusri Engineering College, Hyderabad, 500059, India., Veerabhadraiah M; Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India., Krishna Chaitanya V; Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India., Nagamani M; Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India., Raghavender M; Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India., Jalapathi P; Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India. pochampalli.ou.chemi@gmail.com.
Jazyk: angličtina
Zdroj: Molecular diversity [Mol Divers] 2023 Dec; Vol. 27 (6), pp. 2695-2713. Date of Electronic Publication: 2022 Nov 27.
DOI: 10.1007/s11030-022-10575-6
Abstrakt: Novel 5-((2-(4-bromo/chloro benzoyl) benzofuran-5-yl) methyl)-2-((1-(substituted)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde analogues about twenty-one were synthesized all through standard chemical procedures. The structure of the compounds were confirmed by 1 H NMR, 13 C NMR and Mass spectral analysis after purification. All the compounds were screened for In Vitro lung and cervical cancer activity against A-549 and HeLa cell lines, respectively, by MTT assay protocol using various nanomolar (nM) concentrations. IC 50 value were calculated from cell viability data. 2-(trifluoromethyl)benzyl substituted derivative presented outstanding activity against both the cell lines compared to standard drug doxorubicin. The methoxy, chloro, fluoro and formyl substituted analogues showed a moderate activity and whereas methyl substituted analogues activity was poor. The morphological deformation of both cell lines by best IC 50 value analogues proved as potent inhibitors of cancer cells growth. Molecular docking studies were performed against extracellular signal-regulated kinase 2 and fibroblast growth factor receptor 2 these results are incredibly in agreement with the investigational data.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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