Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Birth Cohort Study.

Autor:	Haapanen MJ; Folkhälsan Research Center, Helsinki, Finland.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mikkola TM; Folkhälsan Research Center, Helsinki, Finland.; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kortelainen L; Folkhälsan Research Center, Helsinki, Finland.; Department of Health and Social Management, University of Eastern Finland, Kuopio, Finland., Jylhävä J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Faculty of Social Sciences (Health Sciences) and Gerontology Research Center, Tampere University, Tampere, Finland., Wasenius NS; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland., Kajantie E; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland., Eriksson JG; Folkhälsan Research Center, Helsinki, Finland.; Department of Obstetrics and Gynecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University Singapore, Singapore., von Bonsdorff MB; Folkhälsan Research Center, Helsinki, Finland.; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2023 Jun 01; Vol. 78 (6), pp. 980-987.
DOI:	10.1093/gerona/glac233
Abstrakt:	Background: Body mass index (BMI) may not be an optimal predictor of frailty as its constituents, lean and fat mass, may have opposite associations with frailty. Methods: A linear mixed model analysis was performed in the Helsinki Birth Cohort Study (n = 2 000) spanning from 57 to 84 years. A 39-item frailty index (FI) was calculated on three occasions over 17 years. Body composition in late midlife included BMI, percent body fat (%BF), waist-to-hip ratio (WHR), lean mass index (LMI), and fat mass index (FMI). Results: Mean FI levels increased by 0.28%/year among men and by 0.34%/year among women. Among women, per each kg/m2 higher BMI and each unit higher %BF the increases in FI levels per year were 0.013 percentage points (PP) steeper (95% CI = 0.004, 0.023) and 0.009 PP steeper (95% CI = 0.002, 0.016) from late midlife into old age. Among men, per each 0.1-unit greater WHR the increase in FI levels was 0.074 PP steeper per year (95% CI = -0.0004, 0.148). Cross-sectionally, greater FMI and LMI in late midlife were associated with higher FI levels but the direction of the association regarding LMI changed after adjustment for FMI. The categories "high FMI and high LMI" and "high FMI and low LMI" showed the highest FI levels relative to the category "low FMI and low LMI". Conclusions: In late midlife, greater adiposity (%BF) among women and abdominal obesity (WHR) among men may predispose to higher levels of frailty from late midlife into old age. Greater lean mass alone may be protective of frailty, but not in the presence of high fat mass. (© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu