MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques.

Autor: DeBarry JD; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA., Nural MV; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA., Pakala SB; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Nayak V; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; Cancer Data Science Initiatives, Frederick National Laboratory for Cancer Research, Post Office Box B, Frederick, MD, 21702, USA., Warrenfeltz S; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA., Humphrey J; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA., Lapp SA; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Cabrera-Mora M; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA., Brito CFA; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Laboratório de Malária, Instituto René Rachou/Fiocruz Minas, Av. Augusto de Lima 1715, Belo Horizonte, MG, 30190 009, Brazil., Jiang J; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA., Saney CL; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Center for Vaccines and Immunology, University of Georgia, Athens, GA, 30605, USA., Hankus A; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Senior Public Health Informaticist, MITRE Corp, Atlanta, GA, 30345, USA., Stealey HM; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA., DeBarry MB; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA., Lackman N; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA., Legall N; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; Interdisciplinary Disease Ecology Across Scales Research Traineeship Program, Institute of Bioinformatics, Center for the Ecology of Infectious Diseases, University of Georgia, Athens, GA, 30602, USA., Lee K; Center for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA, 30332, USA., Tang Y; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Gupta A; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.; Valted Seq, 704 Quince Orchard Rd, Gaithersburg, MD, 20878, USA., Trippe ED; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; Federal Drug Administration, Silver Spring, MD, 20993, USA., Bridger RR; Complex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, GA, 30602, USA., Weatherly DB; Complex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, GA, 30602, USA., Peterson MS; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA., Jiang X; Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Tran V; Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA., Uppal K; Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA., Fonseca LL; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, 32603, USA., Joyner CJ; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Center for Tropical and Emerging Global Disease, University of Georgia, Athens, GA, 30602, USA.; Center for Vaccines and Immunology, Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA., Karpuzoglu E; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Department of Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA., Cordy RJ; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Department of Biology, Wake Forest University, Winston Salem, NC, 27103, USA., Meyer EVS; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Institutional Animal Care and Use Committee, Research Compliance and Research Integrity Office, Emory University, Atlanta, GA, 30322, USA., Wells LL; Complex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, GA, 30602, USA., Ory DS; Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Casma Therapeutics, Cambridge, MA, 02139, USA., Lee FE; Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Lowance Center for Human Immunology, Emory University, Atlanta, GA, 30322, USA., Tirouvanziam R; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Gutiérrez JB; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; Department of Mathematics, Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.; University of Texas at San Antonio, San Antonio, TX, 78249, USA., Ibegbu C; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA., Lamb TJ; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Department of Pathology, University of Utah, Salt Lake City, UT, 84112, USA., Pohl J; Biotechnology Core Facility Branch, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA., Pruett ST; Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; University of Tennessee, Knoxville, TN, 37996, USA., Jones DP; Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA., Styczynski MP; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA., Voit EO; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA., Moreno A; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA., Galinski MR; Emory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA., Kissinger JC; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA. jkissing@uga.edu.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA. jkissing@uga.edu.; Department of Genetics, University of Georgia, Athens, GA, 30602, USA. jkissing@uga.edu.
Jazyk: angličtina
Zdroj: Scientific data [Sci Data] 2022 Nov 24; Vol. 9 (1), pp. 722. Date of Electronic Publication: 2022 Nov 24.
DOI: 10.1038/s41597-022-01755-y
Abstrakt: Plasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for Plasmodium vivax and Plasmodium ovale. Each of these species produces hypnozoites in the liver, which can cause relapsing infections in the blood. Here we present methods and data generated from iterative longitudinal systems biology infection experiments designed and performed by the Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into the biology, pathogenesis, and immune responses of P. cynomolgi in the Macaca mulatta host. Infections were initiated by sporozoite inoculation. Blood and bone marrow samples were collected at defined timepoints for biological and computational experiments and integrative analyses revolving around primary illness, relapse illness, and subsequent disease and immune response patterns. Parasitological, clinical, haematological, immune response, and -omic datasets (transcriptomics, proteomics, metabolomics, and lipidomics) including metadata and computational results have been deposited in public repositories. The scope and depth of these datasets are unprecedented in studies of malaria, and they are projected to be a F.A.I.R., reliable data resource for decades.
(© 2022. The Author(s).)
Databáze: MEDLINE
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