Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review.

Autor:	Vargas-Nadal G; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy., Köber M; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 08193 Bellaterra, Spain., Nsamela A; Elvesys SAS, 172 Rue de Charonne, 75011 Paris, France.; Chair of Physical Chemistry, TU Dresden, 01062 Dresden, Germany., Terenziani F; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy., Sissa C; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy., Pescina S; ADDRes Lab, Department of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy., Sonvico F; ADDRes Lab, Department of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy., Gazzali AM; School of Pharmaceutical Sciences, Universiti Sains Malaysia, USM, Gelugor 11800, Penang, Malaysia., Wahab HA; School of Pharmaceutical Sciences, Universiti Sains Malaysia, USM, Gelugor 11800, Penang, Malaysia., Grisanti L; Division of Theoretical Physics, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia., Olivera ME; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina., Palena MC; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina., Guzman ML; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina., Luciani-Giacobbe LC; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina., Jimenez-Kairuz A; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina., Ventosa N; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 08193 Bellaterra, Spain., Ratera I; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 08193 Bellaterra, Spain., Belfield KD; Department of Chemistry and Environmental Science, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ 07102, USA., Maoz BM; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.; The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 6997801, Israel.
Jazyk:	angličtina
Zdroj:	Pharmaceutics [Pharmaceutics] 2022 Nov 17; Vol. 14 (11). Date of Electronic Publication: 2022 Nov 17.
DOI:	10.3390/pharmaceutics14112498
Abstrakt:	Fluorescent organic nanoparticles (FONs) are a large family of nanostructures constituted by organic components that emit light in different spectral regions upon excitation, due to the presence of organic fluorophores. FONs are of great interest for numerous biological and medical applications, due to their high tunability in terms of composition, morphology, surface functionalization, and optical properties. Multifunctional FONs combine several functionalities in a single nanostructure (emission of light, carriers for drug-delivery, functionalization with targeting ligands, etc.), opening the possibility of using the same nanoparticle for diagnosis and therapy. The preparation, characterization, and application of these multifunctional FONs require a multidisciplinary approach. In this review, we present FONs following a tutorial approach, with the aim of providing a general overview of the different aspects of the design, preparation, and characterization of FONs. The review encompasses the most common FONs developed to date, the description of the most important features of fluorophores that determine the optical properties of FONs, an overview of the preparation methods and of the optical characterization techniques, and the description of the theoretical approaches that are currently adopted for modeling FONs. The last part of the review is devoted to a non-exhaustive selection of some recent biomedical applications of FONs.
Databáze:	MEDLINE
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