Curcumin-Added Whey Protein Positively Modulates Skeletal Muscle Inflammation and Oxidative Damage after Exhaustive Exercise.

Autor:	Dias KA; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., da Conceição AR; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., Pereira SMS; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., Oliveira LA; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., da Silva Rodrigues JV; Department of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., Dias RS; Department of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., de Paula SO; Department of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., Natali AJ; Department of Physical Education, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., da Matta SLP; Department of General Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., Gonçalves RV; Department of Animal Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., Tako E; Department of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USA., Martino HSD; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil., Lucia CMD; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2022 Nov 19; Vol. 14 (22). Date of Electronic Publication: 2022 Nov 19.
DOI:	10.3390/nu14224905
Abstrakt:	(1) Background: Exhaustive exercise can induce muscle damage. The consumption of nutritional compounds with the ability to positively influence the oxidative balance and an exacerbated inflammatory process has been previously studied. However, little is known about the nutritional value of curcumin (CCM) when mixed with whey protein concentrate (WPC). This study was developed to evaluate the effect of CCM-added WPC on inflammatory and oxidative process control and histopathological consequences in muscle tissue submitted to an exhaustive swimming test (ET). (2) Methods: 48 animals were randomly allocated to six groups ( n = 8). An ET was performed 4 weeks after the start of the diet and animals were euthanized 24 h post ET. (3) Results: WPC + CCM and CCM groups reduced IL-6 and increased IL-10 expression in muscle tissue. CCM reduced carbonyl protein after ET compared to standard AIN-93M ET and WPC + CCM ET diets. Higher nitric oxide concentrations were observed in animals that consumed WPC + CCM and CCM. Consumption of WPC + CCM or isolated CCM reduced areas of inflammatory infiltrate and fibrotic tissue in the muscle. (4) Conclusions: WPC + CCM and isolated CCM contribute to the reduction in inflammation and oxidative damage caused by the exhaustive swimming test.
Databáze:	MEDLINE
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