Lacticaseibacillus rhamnosus CA15 (DSM 33960) as a Candidate Probiotic Strain for Human Health.

Autor: Pino A; Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street, 100, 95123 Catania, Italy.; ProBioEtna SRL, Spin Off of the University of Catania, Santa Sofia Street, 100, 95123 Catania, Italy.; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street, 6, 95125 Catania, Italy., Vaccalluzzo A; Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street, 100, 95123 Catania, Italy., Caggia C; Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street, 100, 95123 Catania, Italy.; ProBioEtna SRL, Spin Off of the University of Catania, Santa Sofia Street, 100, 95123 Catania, Italy.; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street, 6, 95125 Catania, Italy., Balzaretti S; Sacco Systems, Alessandro Manzoni Street, 29/A, 22071 Cadorago, Italy., Vanella L; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street, 6, 95125 Catania, Italy.; Department of Drug and Health Science, University of Catania, A. Doria Street, 6, 95125 Catania, Italy., Sorrenti V; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street, 6, 95125 Catania, Italy.; Department of Drug and Health Science, University of Catania, A. Doria Street, 6, 95125 Catania, Italy., Ronkainen A; Human Microbiome Research, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, FI-00014 Helsinki, Finland., Satokari R; Human Microbiome Research, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, FI-00014 Helsinki, Finland., Randazzo CL; Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street, 100, 95123 Catania, Italy.; ProBioEtna SRL, Spin Off of the University of Catania, Santa Sofia Street, 100, 95123 Catania, Italy.; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street, 6, 95125 Catania, Italy.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2022 Nov 19; Vol. 14 (22). Date of Electronic Publication: 2022 Nov 19.
DOI: 10.3390/nu14224902
Abstrakt: Lactobacilli with probiotic properties have emerged as promising tools for both the prevention and treatment of vaginal dysbiosis. The present study aimed to study the in vitro probiotic potential of the Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain isolated from a healthy vaginal ecosystem. The strain was evaluated for both functional (antagonistic activity against pathogens; H 2 O 2 , organic acid, and lactic acid production; antioxidant and anti-inflammatory activities; ability to adhere to intestinal mucus and to both CaCo-2 and VK7/E6E7 cell lines; exopolysaccharide production; surface properties; and ability to survive during gastrointestinal transit) and safety (hemolytic, DNase, and gelatinase activities; mucin degradation ability; production of biogenic amines; and resistance to antimicrobials) characteristics. Data revealed that the tested strain was able to antagonize a broad spectrum of vaginal pathogens. In addition, the adhesion capacity to both vaginal and intestinal cell lines, as well as anti-inflammatory and antioxidant activities, was detected. The ability of the Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain to survive under harsh environmental conditions occurring during the gastrointestinal passage suggests its possible oral delivery. Thus, in vitro data highlighted interesting probiotic properties of the CA15 (DSM 33960) strain, which could represent a valuable candidate for in vivo vaginal infections treatment.
Databáze: MEDLINE
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