Cytokine Profiling in Different SARS-CoV-2 Genetic Variants.

Autor: Korobova ZR; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia.; Intensive Care Unit, Department of Immunology, Department of Infectious Diseases, Pavlov First State Medical University of St. Petersburg, 6-8 Ulitsa L'va Tolstovo, 197022 Saint Petersburg, Russia., Arsentieva NA; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia., Liubimova NE; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia., Batsunov OK; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia.; Intensive Care Unit, Department of Immunology, Department of Infectious Diseases, Pavlov First State Medical University of St. Petersburg, 6-8 Ulitsa L'va Tolstovo, 197022 Saint Petersburg, Russia., Dedkov VG; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia., Gladkikh AS; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia., Sharova AA; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia., Adish Z; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia.; Laboratory of Immunochemistry and Immunobiotechnology, National Center for Biotechnology, 13/5, Kurgalzhynskoye Road, Nur-Sultan 010000, Kazakhstan., Chernykh EI; The Federal State Budgetary Institution 'North-Western District Scientific and Clinical Center Named after L.G. Sokolov Federal Medical and Biological Agency', Prospekt Kul'tury, 4, 194291 Saint Petersburg, Russia., Kaschenko VA; The Federal State Budgetary Institution 'North-Western District Scientific and Clinical Center Named after L.G. Sokolov Federal Medical and Biological Agency', Prospekt Kul'tury, 4, 194291 Saint Petersburg, Russia.; Department of Faculty Surgery, Saint Petersburg State University, Universitetskaya Naberezhnaya, 7/9, 199034 Saint Petersburg, Russia., Ratnikov VA; The Federal State Budgetary Institution 'North-Western District Scientific and Clinical Center Named after L.G. Sokolov Federal Medical and Biological Agency', Prospekt Kul'tury, 4, 194291 Saint Petersburg, Russia.; Scientific, Clinical and Educational Center 'Radiation Diagnostics and Nuclear Medicine' of the Institute of High Medical Technologies, Saint Petersburg State University, Universitetskaya Naberezhnaya, 7/9, 199034 Saint Petersburg, Russia., Gorelov VP; The Federal State Budgetary Institution 'North-Western District Scientific and Clinical Center Named after L.G. Sokolov Federal Medical and Biological Agency', Prospekt Kul'tury, 4, 194291 Saint Petersburg, Russia., Stanevich OV; Intensive Care Unit, Department of Immunology, Department of Infectious Diseases, Pavlov First State Medical University of St. Petersburg, 6-8 Ulitsa L'va Tolstovo, 197022 Saint Petersburg, Russia., Kulikov AN; Intensive Care Unit, Department of Immunology, Department of Infectious Diseases, Pavlov First State Medical University of St. Petersburg, 6-8 Ulitsa L'va Tolstovo, 197022 Saint Petersburg, Russia., Pevtsov DE; Intensive Care Unit, Department of Immunology, Department of Infectious Diseases, Pavlov First State Medical University of St. Petersburg, 6-8 Ulitsa L'va Tolstovo, 197022 Saint Petersburg, Russia., Totolian AA; Saint Petersburg Pasteur Institute, 14 Ulitsa Mira, 197101 Saint Petersburg, Russia.; Intensive Care Unit, Department of Immunology, Department of Infectious Diseases, Pavlov First State Medical University of St. Petersburg, 6-8 Ulitsa L'va Tolstovo, 197022 Saint Petersburg, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 16; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 16.
DOI: 10.3390/ijms232214146
Abstrakt: This study is a successor of our previous work concerning changes in the chemokine profile in infection that are associated with different SARS-CoV-2 genetic variants. The goal of our study was to take into account both the virus and the host immune system by assessing concentrations of cytokines in patients infected with different SARS-CoV-2 variants (ancestral Wuhan strain, Alpha, Delta and Omicron). Our study was performed on 340 biological samples taken from COVID-19 patients and healthy donors in the timespan between May 2020 and April 2022. We performed genotyping of the virus in nasopharyngeal swabs, which was followed by assessment of cytokines' concentration in blood plasma. We noted that out of nearly 30 cytokines, only four showed stable elevation independently of the variant (IL-6, IL-10, IL-18 and IL-27), and we believe them to be 'constant' markers for COVID-19 infection. Cytokines that were studied as potential biomarkers lose their diagnostic value as the virus evolves, and the specter of potential targets for predictive models is narrowing. So far, only four cytokines (IL-6, IL-10, IL-18, and IL-27) showed a consistent rise in concentrations independently of the genetic variant of the virus. Although we believe our findings to be of scientific interest, we still consider them inconclusive; further investigation and comparison of immune responses to different variants of SARS-CoV-2 is required.
Databáze: MEDLINE
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