Ferroptosis Signaling in Pancreatic β-Cells: Novel Insights & Therapeutic Targeting.

Autor: Elumalai S; Innovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, Korea., Karunakaran U; Innovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, Korea., Moon JS; Innovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, Korea.; Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea., Won KC; Innovative Center for Aging Research, Yeungnam University Medical Center, Daegu 42415, Korea.; Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 08; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 08.
DOI: 10.3390/ijms232213679
Abstrakt: Metabolic stress impairs pancreatic β-cell survival and function in diabetes. Although the pathophysiology of metabolic stress is complex, aberrant tissue damage and β-cell death are brought on by an imbalance in redox equilibrium due to insufficient levels of endogenous antioxidant expression in β-cells. The vulnerability of β-cells to oxidative damage caused by iron accumulation has been linked to contributory β-cell ferroptotic-like malfunction under diabetogenic settings. Here, we take into account recent findings on how iron metabolism contributes to the deregulation of the redox response in diabetic conditions as well as the ferroptotic-like malfunction in the pancreatic β-cells, which may offer insights for deciphering the pathomechanisms and formulating plans for the treatment or prevention of metabolic stress brought on by β-cell failure.
Databáze: MEDLINE
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