| Autor: |
Zlatanova HI; Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria., Georgieva-Kotetarova MT; Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria., Vilmosh NB; Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria., Kandilarov IK; Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Nov 09; Vol. 19 (22). Date of Electronic Publication: 2022 Nov 09. |
| DOI: |
10.3390/ijerph192214748 |
| Abstrakt: |
The main symptoms of schizophrenia are categorized as positive, negative, and cognitive. Cognitive impairments do not generally respond to antipsychotics. Cariprazine is a novel antipsychotic conceived with the idea that high affinity for D3 receptors may elicit a favorable response in the management of cognitive deficits. We evaluated the pro-cognitive properties of 14-day long pre-treatment with cariprazine (0.25, 0.5, and 1 mg/kg b.w. intraperitoneally) in experimental rodent models with scopolamine-induced memory impairment employing novel object recognition test (NORT), T-maze, Y-maze, and passive avoidance tasks (step-through and step-down). Statistical analysis was performed with One Way ANOVA. In NORT cariprazine increased the recognition index. In T-maze and Y-maze cariprazine increased the working memory index as well as the percentage of spontaneous alternation. Cariprazine improved learning and memory in both short-term and long-term memory retention tests in step-down and step-through tasks. Cariprazine improves learning, recognition, and spatial memory in rats with scopolamine-induced memory impairment. Cariprazine's beneficial effect on cognition is likely due to its affinity for D3 receptors, as well as agonism at 5-HT1A receptors. Most probably, the cognitive-enhancing properties of cariprazine are the result of integrated modulation in the amygdala, hippocampus, and prefrontal cortex. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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