Restoration of CD4 + T Cells during NAFLD without Modulation of the Hepatic Immunological Pattern Is Not Sufficient to Prevent HCC.

Autor:	Isbell M; Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA.; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA., Mirshahi F; Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA., Aqbi HF; Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA.; College of Science, Mustansiriyah University, Baghdad P.O. Box 14022, Iraq., Guo C; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA.; Department of Human & Molecular Genetics, VCU School of Medicine, Richmond, VA 23298, USA., Saneshaw M; Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA., Koelsch N; Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA.; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA., Idowu MO; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA.; Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA., Austin D; Serpin Pharma, 9501 Discovery Blvd., Suite 120, Manassas, VA 20109, USA., Gelber C; Serpin Pharma, 9501 Discovery Blvd., Suite 120, Manassas, VA 20109, USA., Wang XY; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA.; Department of Human & Molecular Genetics, VCU School of Medicine, Richmond, VA 23298, USA., Sanyal AJ; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA.; Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA., Manjili MH; Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA.; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA.; Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA.
Jazyk:	angličtina
Zdroj:	Cancers [Cancers (Basel)] 2022 Nov 09; Vol. 14 (22). Date of Electronic Publication: 2022 Nov 09.
DOI:	10.3390/cancers14225502
Abstrakt:	Predominant inflammatory immunological patterns as well as the depletion of CD4 + T cells during nonalcoholic fatty liver disease (NAFLD) are reported to be associated with the progression of hepatocellular carcinoma (HCC). Here, we report that an LRP-1 agonistic peptide, SP16, when administered during advanced NAFLD progression, restored the depleted CD4 + T cell population but did not significantly affect the inflammatory immunological pattern. This data suggests that restoration of CD4 + T cells without modulation of the hepatic immunological pattern is not sufficient to prevent HCC. However, SP16 administered early during NAFLD progression modulated the inflammatory profile. Future studies will determine if regulation of the inflammatory immune response by SP16 early in NAFLD progression will prevent HCC.
Databáze:	MEDLINE
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