| Autor: |
Ślebioda TJ; Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland., Stanisławowski M; Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland., Kaszubowska L; Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland., Zaucha JM; Department of Haematology and Transplantology, Medical University of Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland., Żmijewski MA; Department of Histology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland. |
| Abstrakt: |
Chimeric antigen receptor T (CAR-T) cells are genetically modified autologous T cells that have revolutionized the treatment of relapsing and refractory haematological malignancies. In this review we present molecular pathways involved in the activation of CAR-T cells, describe in details the structures of receptors and the biological activity of CAR-T cells currently approved for clinical practice in the European Union, and explain the functional differences between them. Finally, we present the potential for the development of CAR-T cells in Poland, as well as indicate the possible directions of future research in this area, including novel modifications and applications of CAR-T cells and CAR-natural killer (NK) cells. |
