Rapid volumetric brain changes after acute psychosocial stress.

Autor: Uhlig M; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; International Max Planck Research School NeuroCom, Leipzig, Germany. Electronic address: muhlig@cbs.mpg.de., Reinelt JD; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Lauckner ME; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Independent Research Group 'Adaptive Memory', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Medical Faculty of Leipzig University, Leipzig, Germany., Kumral D; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Institute of Psychology, Neuropsychology, University of Freiburg, Freiburg im Breisgau, Germany., Schaare HL; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Otto Hahn Group 'Cognitive Neurogenetics', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Germany., Mildner T; NMR Methods & Development Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Babayan A; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; MindBrainBody Institute at the Berlin School of Mind and Brain, Faculty of Philosophy, Humboldt-Universität zu Berlin, Berlin, German., Möller HE; NMR Methods & Development Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Engert V; Institute of Psychosocial Medicine, Psychotherapy and Psychooncology, Jena University Hospital, Friedrich-Schiller University, Jena, Germany; Independent Research Group 'Social Stress and Family Health', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Villringer A; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; MindBrainBody Institute at the Berlin School of Mind and Brain, Faculty of Philosophy, Humboldt-Universität zu Berlin, Berlin, German., Gaebler M; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; MindBrainBody Institute at the Berlin School of Mind and Brain, Faculty of Philosophy, Humboldt-Universität zu Berlin, Berlin, German.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2023 Jan; Vol. 265, pp. 119760. Date of Electronic Publication: 2022 Nov 24.
DOI: 10.1016/j.neuroimage.2022.119760
Abstrakt: Stress is an important trigger for brain plasticity: Acute stress can rapidly affect brain activity and functional connectivity, and chronic or pathological stress has been associated with structural brain changes. Measures of structural magnetic resonance imaging (MRI) can be modified by short-term motor learning or visual stimulation, suggesting that they also capture rapid brain changes. Here, we investigated volumetric brain changes (together with changes in T1 relaxation rate and cerebral blood flow) after acute stress in humans as well as their relation to psychophysiological stress measures. Sixty-seven healthy men (25.8±2.7 years) completed a standardized psychosocial laboratory stressor (Trier Social Stress Test) or a control version while blood, saliva, heart rate, and psychometrics were sampled. Structural MRI (T1 mapping / MP2RAGE sequence) at 3T was acquired 45 min before and 90 min after intervention onset. Grey matter volume (GMV) changes were analysed using voxel-based morphometry. Associations with endocrine, autonomic, and subjective stress measures were tested with linear models. We found significant group-by-time interactions in several brain clusters including anterior/mid-cingulate cortices and bilateral insula: GMV was increased in the stress group relative to the control group, in which several clusters showed a GMV decrease. We found a significant group-by-time interaction for cerebral blood flow, and a main effect of time for T1 values (longitudinal relaxation time). In addition, GMV changes were significantly associated with state anxiety and heart rate variability changes. Such rapid GMV changes assessed with VBM may be induced by local tissue adaptations to changes in energy demand following neural activity. Our findings suggest that endogenous brain changes are counteracted by acute psychosocial stress, which emphasizes the importance of considering homeodynamic processes and generally highlights the influence of stress on the brain.
Competing Interests: Conflict of Interest We have no conflicts of interest to declare.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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