| Autor: |
Perim Galvão De Podestá O; Research Group on Epidemiology, Healf and Nutrition, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.; Sciences of Fundacion Antonio Prudente, A C Camargo Cancer Center, São Paulo, São paulo, Brazil., Salaroli LB; Graduate Program in Collective Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.; Graduate Program in Nutrition and Health, Vitória, Espírito Santo, Brazil., Cattafesta M; Research Group on Epidemiology, Healf and Nutrition, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil., Peres SV; Onconcenter Foundation of São Paulo - Deputy Director of Information and Epidemiology, São paulo, Brazil., De Podestá JRV; Santa Rita de Cássia Hospital (AFECC), Vitória, Espírito Santo, Brazil., von Zeidler SLV; Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil., de Oliveira JC; Association to Combat Cancer in Goiás Hospital Araújo Jorge, Goiânia, Goiás, Brazil., Kowalski LP; Sciences of Fundacion Antonio Prudente, A C Camargo Cancer Center, São Paulo, São paulo, Brazil., Ikeda MK; Sciences of Fundacion Antonio Prudente, A C Camargo Cancer Center, São Paulo, São paulo, Brazil., Brennan P; International Agency for Research on Cancer, Lyon, France., Curado MP; Sciences of Fundacion Antonio Prudente, A C Camargo Cancer Center, São Paulo, São paulo, Brazil. |
| Abstrakt: |
Head and neck cancer (HNC) significantly impacts nutritional status because the tumor limits swallowing function. In this sense, it is important to monitor the nutritional status throughout the life of any individual. A multicenter case-control study was carried out to analyze the BMI at 30 years of age, two years before diagnosis and at the time of diagnosis of individuals with oral cavity, oropharynx, and larynx cancers. It was observed that a 5% reduction in BMI during the two years before enrollment was associated with an increased risk of the oral cavity (OR = 3.73), oropharyngeal OR = 5.25), and laryngeal (OR = 5.22). Reduced BMI of more than 5% over two years before diagnosis was associated with HNC. Weight loss remained significant at diagnosis, but it is not possible to exclude reverse causality since most cases are at an advanced stage. BMI monitoring of individuals at potential risk for HNC can promote early diagnosis and nutritional interventions for HNC. |
