Spatial, environmental, and individual associations with Anopheles albimanus salivary antigen IgG in Haitian children.

Autor:	Jaramillo-Underwood A; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States.; Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN, United States., Herman C; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Impoinvil D; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Sutcliff A; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Knipes A; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Worrell CM; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Fox LM; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Desir L; The Carter Center, Atlanta, GA, United States., Fayette C; IMA World Health, Port-au-Prince, Haiti., Javel A; IMA World Health, Port-au-Prince, Haiti., Monestime F; IMA World Health, Port-au-Prince, Haiti., Mace KE; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Chang MA; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Lemoine JF; Programme National de Contrôle de la Malaria, Ministère de la Santé Publique et de la Population (MSPP), Port-au-Prince, Haiti., Won K; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Udhayakumar V; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States., Rogier E; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Nov 08; Vol. 12, pp. 1033917. Date of Electronic Publication: 2022 Nov 08 (Print Publication: 2022).
DOI:	10.3389/fcimb.2022.1033917
Abstrakt:	IgG serology can be utilized to estimate exposure to Anopheline malaria vectors and the Plasmodium species they transmit. A multiplex bead-based assay simultaneously detected IgG to Anopheles albimanus salivary gland extract (SGE) and four Plasmodium falciparum antigens (CSP, LSA-1, PfAMA1, and PfMSP1) in 11,541 children enrolled at 350 schools across Haiti in 2016. Logistic regression estimated odds of an above-median anti-SGE IgG response adjusting for individual- and environmental-level covariates. Spatial analysis detected statistically significant clusters of schools with students having high anti-SGE IgG levels, and spatial interpolation estimated anti-SGE IgG levels in unsampled locations. Boys had 11% (95% CI: 0.81, 0.98) lower odds of high anti-SGE IgG compared to girls, and children seropositive for PfMSP1 had 53% (95% CI: 1.17, 2.00) higher odds compared to PfMSP1 seronegatives. Compared to the lowest elevation, quartiles 2-4 of higher elevation were associated with successively lower odds (0.81, 0.43, and 0.34, respectively) of high anti-SGE IgG. Seven significant clusters of schools were detected in Haiti, while spatially interpolated results provided a comprehensive picture of anti-SGE IgG levels in the study area. Exposure to malaria vectors by IgG serology with SGE is a proxy to approximate vector biting in children and identify risk factors for vector exposure. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Jaramillo-Underwood, Herman, Impoinvil, Sutcliff, Knipes, Worrell, Fox, Desir, Fayette, Javel, Monestime, Mace, Chang, Lemoine, Won, Udhayakumar and Rogier.)
Databáze:	MEDLINE
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