The genetic legacy of the Hunyadi descendants.

Autor:	Neparáczki E; Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary.; Department of Genetics, University of Szeged, Szeged, Hungary., Kis L; Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary.; Department of Biological Anthropology, University of Szeged, Szeged, Hungary., Maróti Z; Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary.; Department of Pediatrics and Pediatric Health Center, University of Szeged, Szeged, Hungary., Kovács B; Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary.; Department of Genetics, University of Szeged, Szeged, Hungary., Varga GIB; Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary., Makoldi M; Department of Archaeology, Institute of Hungarian Research, Budapest, Hungary., Horolma P; Institute of Forensic Genetics, Hungarian Institute for Forensic Sciences, Budapest, Hungary., Éva Teiszler; Department of History, Institute of Hungarian Research, Budapest, Hungary., Tihanyi B; Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary.; Department of Biological Anthropology, University of Szeged, Szeged, Hungary., Nagy PL; Praxis Genomics LLC, Atlanta, GA, USA., Maár K; Department of Genetics, University of Szeged, Szeged, Hungary., Gyenesei A; Genomics and Bioinformatics Core Facility, Szentágothai Research Centre, University of Pécs, Pécs, Hungary., Schütz O; Department of Genetics, University of Szeged, Szeged, Hungary., Dudás E; Institute of Forensic Genetics, Hungarian Institute for Forensic Sciences, Budapest, Hungary., Török T; Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary.; Department of Genetics, University of Szeged, Szeged, Hungary., Pascuttini-Juraga V; Ministry of Culture and Media, Conservation Department in Varaždin for the Areas of the Varaždin and Međimurje Counties, Varazdin, Croatia., Peharda I; Ministry of Culture and Media, Conservation Department in Varaždin for the Areas of the Varaždin and Međimurje Counties, Varazdin, Croatia., Vizi LT; Department of History, Institute of Hungarian Research, Budapest, Hungary., Horváth-Lugossy G; Institute of Hungarian Research, Budapest, Hungary., Kásler M; National Institute of Oncology, Budapest, Hungary.; Minister of Human Capacities of the Republic of Hungary, Budapest, Hungary.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2022 Nov 17; Vol. 8 (11), pp. e11731. Date of Electronic Publication: 2022 Nov 17 (Print Publication: 2022).
DOI:	10.1016/j.heliyon.2022.e11731
Abstrakt:	The Hunyadi family is one of the most influential families in the history of Central Europe in the 14th-16th centuries. The family's prestige was established by Johannes Hunyadi, a Turk-beater who rose to the position of governor of the Kingdom of Hungary. His second son, Matthias Hunyadi, became the elected ruler of the Kingdom of Hungary in 1458. The Hunyadi family had unknown origin. Moreover, Matthias failed to found a dynasty because of lacking a legitimate heir and his illegitimate son Johannes Corvinus was unable to obtain the crown. His grandson, Christophorus Corvinus, died in childhood, thus the direct male line of the family ended. In the framework of on interdisciplinary research, we have determined the whole genome sequences of Johannes Corvinus and Christophorus Corvinus by next-generation sequencing technology. Both of them carried the Y-chromosome haplogroup is E1b1b1a1b1a6a1c ∼, which is widespread in Eurasia. The father-son relationship was verified using the classical STR method and whole genome data. Christophorus Corvinus belongs to the rare, sporadically occurring T2c1+146 mitochondrial haplogroup, most frequent around the Mediterranean, while his father belongs to the T2b mitochondrial haplogroup, widespread in Eurasia, both are consistent with the known origin of the mothers. Archaeogenomic analysis indicated that the Corvinus had an ancient European genome composition. Based on the reported genetic data, it will be possible to identify all the other Hunyadi family member, whose only known grave site is known, but who are resting assorted with several other skeletons. Competing Interests: The authors declare the following conflict of interests: Péter L. Nagy is sole owner of Praxis Genomics LLC was not directly involved in the design and execution of the experiments of the manuscript. This affiliation does not alter our adherence to Heliyon policies on sharing data and materials. All other authors have no conflict to declare. (© 2022 The Author(s).)
Databáze:	MEDLINE
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