Long-Term CD4 + T-Cell and Immunoglobulin G Immune Responses in Oncology Workers following COVID-19 Vaccination: An Interim Analysis of a Prospective Cohort Study.

Autor:	Gallen C; Department of Clinical Science, Moffitt Cancer Center, Tampa, FL 33612, USA., Dukes CW; Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612, USA., Aldrich A; Department of Clinical Science, Moffitt Cancer Center, Tampa, FL 33612, USA., Macaisa L; Department of Clinical Science, Moffitt Cancer Center, Tampa, FL 33612, USA., Mo Q; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL 33612, USA., Cubitt CL; Immune Monitoring Core Facility, Moffitt Cancer Center, Tampa, FL 33612, USA., Pilon-Thomas S; Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612, USA.; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL 33612, USA., Giuliano AR; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL 33612, USA.; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USA., Czerniecki BJ; Department of Clinical Science, Moffitt Cancer Center, Tampa, FL 33612, USA.; Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612, USA.; Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA., Costa RLB; Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2022 Nov 15; Vol. 10 (11). Date of Electronic Publication: 2022 Nov 15.
DOI:	10.3390/vaccines10111931
Abstrakt:	We conducted a prospective study to evaluate immune responses to SARS-CoV-2 in oncology workers in which we collected blood and clinical data every 6 months. Spike-specific CD4 + T-cells and immunoglobulin G responses were measured using interferon-gamma enzyme-linked immunosorbent spot and enzyme-linked immunosorbent assay, respectively. Sixty (81%) vaccinated and 14 (19%) unvaccinated individuals were enrolled. CD4 + T-cell responses of those individuals currently naturally infected were comparable to those who were 6 months from receiving their last dose of the vaccine; both responses were significantly higher than among those who were unvaccinated. Unvaccinated participants who became vaccinated while in the study showed a significant increase in both types of spike-specific immune responses. Previously vaccinated individuals who received a third dose (booster) showed a similar response to the spike protein. However, this response decreases as soon as 3 months but does not dip below the established response following two doses. Response to variants of concern B.1.617.2 (Delta) and B.1.1.529 (Omicron) also increased, with the Omicron variant having a significantly lower response when compared to Delta and the wild type. We conclude that antibody and T-cell responses increase in oncology workers after serial vaccination but can wane over time.
Databáze:	MEDLINE
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