Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina.

Autor: Uschner D; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Bott M; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Lagarde WH; Division of Pediatric Endocrinology, Department of Pediatrics, WakeMed Health and Hospitals, Raleigh, NC 27610, USA., Keating J; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA., Tapp H; Department of Family Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28262, USA., Berry AA; Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Seals AL; Division of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA., Munawar I; Division of Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA., Schieffelin J; Section of Infectious Disease, Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Yukich J; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA., Santacatterina M; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Gunaratne M; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Fette LM; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Burke B; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Strylewicz G; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Edelstein SL; The Biostatistics Center, George Washington University, Rockville, MD 20852, USA., Ahmed A; Department of Pediatrics, Atrium Health Levine Children's Hospital, Charlotte, NC 28203, USA., Miller K; MedStar Health Research Institute, Georgetown University, Washington, DC 20007, USA., Sanders JW; Division of Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA., Herrington D; Division of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA., Weintraub WS; MedStar Health Research Institute, Georgetown University, Washington, DC 20007, USA., Runyon MS; Department of Emergency Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28262, USA., On Behalf Of The Covid-Community Research Partnership
Jazyk: angličtina
Zdroj: Vaccines [Vaccines (Basel)] 2022 Nov 13; Vol. 10 (11). Date of Electronic Publication: 2022 Nov 13.
DOI: 10.3390/vaccines10111922
Abstrakt: We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.
Databáze: MEDLINE