Simulated Microgravity Created Using a Random Positioning Machine Induces Changes in the Physiology of the Fusarium solani Species Complex.

Autor: D'Agostino M; UR 7300 SIMPA, Stress Immunity Pathogens Laboratory, Faculty of Medicine, Lorraine University, 9 Avenue de la Forêt de Haye, F-54500 Vandœuvre-lès-Nancy, France., Babin AL; UR 7300 SIMPA, Stress Immunity Pathogens Laboratory, Faculty of Medicine, Lorraine University, 9 Avenue de la Forêt de Haye, F-54500 Vandœuvre-lès-Nancy, France., Zaffino M; UR 7300 SIMPA, Stress Immunity Pathogens Laboratory, Faculty of Medicine, Lorraine University, 9 Avenue de la Forêt de Haye, F-54500 Vandœuvre-lès-Nancy, France., Frippiat JP; UR 7300 SIMPA, Stress Immunity Pathogens Laboratory, Faculty of Medicine, Lorraine University, 9 Avenue de la Forêt de Haye, F-54500 Vandœuvre-lès-Nancy, France., Machouart M; UR 7300 SIMPA, Stress Immunity Pathogens Laboratory, Faculty of Medicine, Lorraine University, 9 Avenue de la Forêt de Haye, F-54500 Vandœuvre-lès-Nancy, France.; Service de Microbiologie, CHRU de Nancy, Hôpitaux de Brabois, 11 Allée du Morvan, 54511 Vandœuvre-lès-Nancy, France., Debourgogne A; UR 7300 SIMPA, Stress Immunity Pathogens Laboratory, Faculty of Medicine, Lorraine University, 9 Avenue de la Forêt de Haye, F-54500 Vandœuvre-lès-Nancy, France.; Service de Microbiologie, CHRU de Nancy, Hôpitaux de Brabois, 11 Allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
Jazyk: angličtina
Zdroj: Microorganisms [Microorganisms] 2022 Nov 16; Vol. 10 (11). Date of Electronic Publication: 2022 Nov 16.
DOI: 10.3390/microorganisms10112270
Abstrakt: Fusarium is a phytopathogenic fungus involved in human pathology and is present in space stations. It is essential to understand the effects of microgravity on the physiology of this fungus to determine the potential risks to the health of crew members and to propose the necessary countermeasures. This study aimed to determine changes in the physiological parameters of the Fusarium solani species complex under simulated microgravity generated using a random positioning machine (RPM) and phenotypic approaches. We observed increased growth, spore production, and germination while biofilm production was reduced under RPM exposure. These in vitro data show the importance of further studying this fungus as it has been repeatedly demonstrated that microgravity weakens the immune system of astronauts.
Databáze: MEDLINE
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