Effects of Photobiomodulation in Patients Presenting with Reticular Pseudodrusen: A Retrospective Observational Case Series Study.

Autor:	Le HM; Centre Hospitalier Intercommunal de Créteil, 94 000 Créteil, France.; Faculty of Medicine, University Paris-Est Créteil (UPEC), 94 000 Créteil, France., Mehanna CJ; Centre Hospitalier Intercommunal de Créteil, 94 000 Créteil, France., De Rosa I; Centre Hospitalier Intercommunal de Créteil, 94 000 Créteil, France., Miere A; Centre Hospitalier Intercommunal de Créteil, 94 000 Créteil, France.; Faculty of Medicine, University Paris-Est Créteil (UPEC), 94 000 Créteil, France., Souied E; Centre Hospitalier Intercommunal de Créteil, 94 000 Créteil, France.; Faculty of Medicine, University Paris-Est Créteil (UPEC), 94 000 Créteil, France.
Jazyk:	angličtina
Zdroj:	Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2022 Nov 17; Vol. 58 (11). Date of Electronic Publication: 2022 Nov 17.
DOI:	10.3390/medicina58111662
Abstrakt:	Background and Objectives : The purpose of this study is to describe the effects of photobiomodulation on drusen regression with patients presenting with reticular pseudodrusen (RPD). Materials and Methods : This study is a retrospective observational case series study including patients presenting with RPD who underwent treatment by photobiomodulation. All patients underwent a complete ophthalmic examination and multimodal imaging prior to treatment, including spectral-domain optical coherence tomography (SD-OCT). Eyes were treated two times per week for six consecutive weeks. Best corrected-visual acuity (BVCA) was measured prior and after treatment for all patients. The number of RPD on the SD-OCT scans centered on the macula and stages of RPD was noted at baseline and 6 months after the first treatment session. Results : Five eyes of five patients were included in the study. Mean BCVA did not change 6 months after treatment compared to baseline. Mean number of RPD per eye was 112.60 +/- 48.33 RPD at baseline and 111.6 +/- 49.29 in the same area 6 months after treatment. Changes in RPD distribution according to RPD classification were observed before and after treatment with photobiomodulation. Changes in distribution mostly concerned stages 1 and 3 RPD: Total number of stage 1 RPD was 289 and increased to 324 after treatment. Total number of stage 3 RPD was 97 at baseline and decreased to 67 6 months after treatment. Percentage of stage 1 RPD increased from 46% to 56% after treatment. Percentage of stage 3 RPD decreased from 20% to 13% after treatment. Conclusions : Changes in RPD distribution were observed before and after treatment with photobiomodulation. The number of stage 3 reticular pseudodrusen decreased while number of stage 1 reticular pseudodrusen increased after treatment.
Databáze:	MEDLINE
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