Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS.

Autor:	Pan Y; Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USA., Wang D; Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USA., Chaudhary MFA; The Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA., Shao W; Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA., Gerard SE; The Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA., Durumeric OC; Department of Mathematics, University of Iowa, Iowa City, IA 52242, USA., Bhatt SP; UAB Lung Imaging Core, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Barr RG; Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA., Hoffman EA; The Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA.; Department of Radiology, University of Iowa, Iowa City, IA 52242, USA., Reinhardt JM; The Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA.; Department of Radiology, University of Iowa, Iowa City, IA 52242, USA., Christensen GE; Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242, USA.; Department of Radiology, University of Iowa, Iowa City, IA 52242, USA.
Jazyk:	angličtina
Zdroj:	Journal of imaging [J Imaging] 2022 Nov 16; Vol. 8 (11). Date of Electronic Publication: 2022 Nov 16.
DOI:	10.3390/jimaging8110309
Abstrakt:	Chronic obstructive pulmonary disease (COPD) is an umbrella term used to define a collection of inflammatory lung diseases that cause airflow obstruction and severe damage to the lung parenchyma. This study investigated the robustness of image-registration-based local biomechanical properties of the lung in individuals with COPD as a function of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Image registration was used to estimate the pointwise correspondences between the inspiration (total lung capacity) and expiration (residual volume) computed tomography (CT) images of the lung for each subject. In total, three biomechanical measures were computed from the correspondence map: the Jacobian determinant; the anisotropic deformation index (ADI); and the slab-rod index (SRI). CT scans from 245 subjects with varying GOLD stages were analyzed from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). Results show monotonic increasing or decreasing trends in the three biomechanical measures as a function of GOLD stage for the entire lung and on a lobe-by-lobe basis. Furthermore, these trends held across all five image registration algorithms. The consistency of the five image registration algorithms on a per individual basis is shown using Bland-Altman plots.
Databáze:	MEDLINE
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