Development of a capillary electrophoretic method for determination of ketorolac enantiomers in human plasma using cationic β-cyclodextrin derivative as a chiral selector.
Autor: | Kravchenko AV; Institute of Chemistry, The Department of Organic Chemistry, Saint Petersburg State University, Saint Petersburg, Russia., Kolobova EA; Institute of Chemistry, The Department of Organic Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.; The Federal State Institute of Public Health 'The Nikiforov Russian Center of Emergency and Radiation Medicine', The Ministry of Russian Federation for Civil Defence, Emergencies and Elimination of Consequences of Natural Disasters, Saint Petersburg, Russia., Kechin AA; Institute of Chemistry, The Department of Organic Chemistry, Saint Petersburg State University, Saint Petersburg, Russia., Kartsova LA; Institute of Chemistry, The Department of Organic Chemistry, Saint Petersburg State University, Saint Petersburg, Russia. |
---|---|
Jazyk: | angličtina |
Zdroj: | Journal of separation science [J Sep Sci] 2023 Jan; Vol. 46 (2), pp. e2200601. Date of Electronic Publication: 2022 Dec 11. |
DOI: | 10.1002/jssc.202200601 |
Abstrakt: | A novel approach for the separation of ketorolac enantiomers by capillary electrophoresis is presented. A cationic β-cyclodextrin derivative based on imidazole was synthesized and used as a chiral selector in the background electrolyte. The influence of pH and ionic strength of background electrolyte, as well as cationic β-cyclodextrin derivative concentration on the resolution of ketorolac enantiomers, was investigated. The highest value of the resolution for ketorolac enantiomers was 1.46 when the background electrolyte consisted of 25 mM NaH (© 2022 Wiley-VCH GmbH.) |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |