Spatio-temporal optical coherence tomography provides full thickness imaging of the chorioretinal complex.

Autor:	Auksorius E; International Center for Translational Eye Research (ICTER), ul. Skierniewicka 10a, 01-230 Warsaw, Poland.; Center for Physical Sciences and Technology (FTMC), Saulėtekio al. 3, LT-10257 Vilnius, Lithuania.; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland., Borycki D; International Center for Translational Eye Research (ICTER), ul. Skierniewicka 10a, 01-230 Warsaw, Poland.; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland., Wegrzyn P; International Center for Translational Eye Research (ICTER), ul. Skierniewicka 10a, 01-230 Warsaw, Poland.; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.; Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw, Poland., Sikorski BL; Department of Ophthalmology, Nicolaus Copernicus University, Skłodowskiej-Curie 9, 85-090 Bydgoszcz, Poland.; Oculomedica, Eye Research & Development Center, Ogrody 14, 85-870 Bydgoszcz, Poland., Lizewski K; International Center for Translational Eye Research (ICTER), ul. Skierniewicka 10a, 01-230 Warsaw, Poland.; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland., Zickiene I; Center for Physical Sciences and Technology (FTMC), Saulėtekio al. 3, LT-10257 Vilnius, Lithuania., Rapolu M; International Center for Translational Eye Research (ICTER), ul. Skierniewicka 10a, 01-230 Warsaw, Poland.; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland., Adomavicius K; Center for Physical Sciences and Technology (FTMC), Saulėtekio al. 3, LT-10257 Vilnius, Lithuania., Tomczewski S; International Center for Translational Eye Research (ICTER), ul. Skierniewicka 10a, 01-230 Warsaw, Poland.; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland., Wojtkowski M; International Center for Translational Eye Research (ICTER), ul. Skierniewicka 10a, 01-230 Warsaw, Poland.; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2022 Nov 05; Vol. 25 (12), pp. 105513. Date of Electronic Publication: 2022 Nov 05 (Print Publication: 2022).
DOI:	10.1016/j.isci.2022.105513
Abstrakt:	Despite the rapid development of optical imaging methods, high-resolution in vivo imaging with penetration into deeper tissue layers is still a major challenge. Optical coherence tomography (OCT) has been used successfully for non-invasive human retinal volumetric imaging in vivo , advancing the detection, diagnosis, and monitoring of various retinal diseases. However, there are important limitations of volumetric OCT imaging, especially coherent noise and the limited axial range over which high resolution images can be acquired. The limited range prevents simultaneous measurement of the retina and choroid with adequate lateral resolution. In this article, we address these limitations with a technique that we term spatio-temporal optical coherence tomography (STOC-T), which uses light with controlled spatial and temporal coherence and advanced signal processing methods. STOC-T enabled the acquisition of high-contrast and high-resolution coronal projection images of the retina and choroid at arbitrary depths. Competing Interests: M.W. and D.B. are founders and shareholders of InCelVu start-up company. Other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2022 The Author(s).)
Databáze:	MEDLINE
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