Sex-dependent vascular effects of cadmium sub-chronic exposure on rats.

Autor: de Oliveira TF; Department of Physiological Sciences, Universidade Federal do Espírito Santo, Vitória, ES, Brazil. thiago13.oliveira@hotmail.com., Rossi EM; Department of Physiological Sciences, Universidade Federal do Espírito Santo, Vitória, ES, Brazil., da Costa CS; Department of Morphology, Health Sciences Center, Universidade Federal do Espirito Santo, Vitória, ES, Brazil., Graceli JB; Department of Morphology, Health Sciences Center, Universidade Federal do Espirito Santo, Vitória, ES, Brazil., Krause M; Department of Chemistry, Universidade Federal do Espirito Santo, Vitória, ES, Brazil., Carneiro MTWD; Department of Chemistry, Universidade Federal do Espirito Santo, Vitória, ES, Brazil., Almenara CCP; Biological Science and Health Center, Universidade Federal do Oeste da Bahia, Barreiras, BA, Brazil., Padilha AS; Department of Physiological Sciences, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
Jazyk: angličtina
Zdroj: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2023 Feb; Vol. 36 (1), pp. 189-199. Date of Electronic Publication: 2022 Nov 23.
DOI: 10.1007/s10534-022-00470-w
Abstrakt: Cadmium exposure is related to several cardiovascular diseases, such as hypertension, atherosclerosis and endothelial dysfunction. However, the toxic effect of cadmium can be dependent on the sex when examined sex in experimental models. The aim of this study was to analyze the effects of cadmium exposure on the cardiovascular system of male and female rodents. The experiments were carried out on both-sexes Wistar at 4 months of age, where from 3 months onwards, cadmium (CdCl2 100 mg/l in placed the drinking water for 30 days) or vehicle delivered (distilled water) was ingested. Before and after 30 days of exposure to cadmium, systolic blood pressure was regularly measured. After exposure, blood was collected to measure dosage of cadmium, in male and female, and estrogen in females. Vascular reactivity to phenylephrine (Phe), acetylcholine (ACh), and sodium nitroprusside (SNP) was studied at respective isolated aortic segments. After the period to Cd-exposure, systolic blood pressure was increased only in the male rats. Males also had higher levels of plasma cadmium than those of female rats, and exposure to the metal did not affect the amount of estrogen produced in the female rats. Increased myeloperoxidase (MPO) activity was also observed in both the males and females that had been exposed to the metal. Moreover, exposure to the cadmium reduced the ACh relaxation and increased vascular reactivity to Phe, resulting in an imbalance between nitric oxide superoxide anion in the isolated aorta of male rats. In female rats, sub-chronic cadmium exposure did not modify the vascular reactivity to Phe and neither to the ACh. The present study revealed that the Cd exposure for 30 days induced sex-dependent cardiovascular abnormalities.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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