The nonindustrialised microbiome in a modern world.

Autor:	Shanahan F; Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland.; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland., Ghosh TS; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland.; Department of Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), New Delhi, India., Molloy MG; Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland.; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland., O'Toole PW; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland.; School of Microbiology, University College Cork, National University of Ireland, Cork, IrelandTraveller.
Jazyk:	angličtina
Zdroj:	Clinical science (London, England : 1979) [Clin Sci (Lond)] 2022 Nov 30; Vol. 136 (22), pp. 1683-1690.
DOI:	10.1042/CS20220203
Abstrakt:	The microbiome contributes to human development and maturation, and is essential for maintenance of health and prevention of disease. While the human genome encodes one's identity, the microbiome - also individually unique - provides a window on one's lifestyle and exposure to environmental variables. The microbiome thus serves as a biomarker of host health and a driver of certain diseases. However, current understanding of the gut microbiome is largely based on studies of industrialised peoples of North America and Europe. Gaps in knowledge of the microbiomes of other groups, particularly those in developing or nonindustrialised societies, are important, particularly in view of contrasting epidemiological risks of acquiring chronic inflammatory and metabolic disorders. Here, we explore underlying mechanisms of microbiome differences and whether the potential benefits of nonindustrialised microbiome can be realised in a modern world. (© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
Databáze:	MEDLINE
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