In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey.

Autor:	Sarıgül Yıldırım F; Department of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, Antalya, Turkey., Üser Ü; Department of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, Antalya, Turkey., Sarı ND; Department of Infectious Diseases, Haseki Education Research Hospital, İstanbul, Turkey., Kurtaran B; Department of Infectious Diseases and Clinical Microbiology, Çukurova University Faculty of Medicine, Adana, Turkey., Önlen Y; Department of Infectious Diseases and Clinical Microbiology, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey., Şenateş E; Department of Gastroenterology, Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey., Gündüz A; Department of Infectious Diseases, İstanbul Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey., Zerdali E; Department of Infectious Diseases, Haseki Education Research Hospital, İstanbul, Turkey., Karsen H; Department of Infectious Diseases and Clinical Microbiology, Harran University Faculty of Medicine, Şanlıurfa, Turkey., Batırel A; Department of Infectious Diseases, İstanbul Doctor Lütfi Kırdar Kartal Training and Research Hospital, İstanbul, Turkey., Karaali R; Department of Infectious Diseases and Clinical Microbiology, Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Güner R; Department of Infectious Diseases and Clinical Microbiology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey., Yamazhan T; Department of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, İzmir, Turkey., Köse Ş; Department of Infectious Diseases, İzmir Tepecik Training and Research Hospital, İzmir, Turkey., Erben N; Department of Infectious Diseases and Clinical Microbiology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey., İnce N; Department of Infectious Diseases and Clinical Microbiology, Düzce University Medical School, Düzce, Turkey., Köksal İ; Department of Infectious Diseases and Clinical Microbiology, Karadeniz Teknik University Faculty of Medicine, Trabzon, Turkey., Çuvalcı Öztoprak N; Department of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, Antalya, Turkey., Yörük G; Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey., Kömür S; Department of Infectious Diseases and Clinical Microbiology, Çukurova University Faculty of Medicine, Adana, Turkey., Bal T; Department of Gastroenterology, Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey., Kaya S; Department of Infectious Diseases and Clinical Microbiology, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Turkey., Bozkurt İ; Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey., Günal Ö; Department of Infectious Diseases, Samsun Education Research Hospital, Samsun, Turkey., Yıldız İE; Department of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Turkey., İnan D; Department of Infectious Diseases and Clinical Microbiology, Akdeniz University Medical School, Antalya, Turkey., Barut Ş; Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpaşa University Medical Faculty, Tokat, Turkey., Namıduru M; Department of Infectious Diseases and Clinical Microbiology, Gaziantep University Medical Faculty, Gaziantep, Turkey., Tosun S; Department of Infectious Diseases and Clinical Microbiology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey., Türker K; Department of Infectious Diseases, İstanbul Bağcılar Training and Research Hospital, İstanbul, Turkey., Şener A; Department of Infectious Diseases and Clinical Microbiology, Çanakkale 18 Mart University Faculty of Medicine, Çanakkale, Turkey., Hızel K; Department of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey., Baykam N; Department of Infectious Diseases and Clinical Microbiology, Hitit University Faculty of Medicine, Çorum, Turkey., Duygu F; Department of Infectious Diseases, Ankara Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey., Bodur H; Department of Infectious Diseases, Ankara Numune Training and Research Hospital, Ankara, Turkey., Can G; Department of Gastroenterology, Bolu İzzet Baysal University Medical Faculty, Bolu, Turkey., Gül HC; Department of Infectious Diseases, Health Science University Gülhane Faculty of Medicine, Ankara, Turkey., Sağmak Tartar A; Department of Infectious Diseases and Clinical Microbiology, Fırat University School of Medicine, Elazığ, Turkey., Çelebi G; Department of Infectious Diseases and Clinical Microbiology, Zonguldak Bülent Ecevit University Training and Research Hospital, Zonguldak, Turkey., Sünnetçioğlu M; Department of Infectious Diseases and Clinical Microbiology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey., Karabay O; Department of Infectious Diseases and Clinical Microbiology, Sakarya University Training and Research Hospital, Sakarya, Turkey., Kumbasar Karaosmanoğlu H; Department of Infectious Diseases, İstanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey., Sırmatel F; Department of Infectious Diseases and Clinical Microbiology, Bolu İzzet Baysal University Medical Faculty, Bolu, Turkey., Tabak F; Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpasa University Medical Faculty, Tokat, Turkey.
Jazyk:	angličtina
Zdroj:	The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2022 Nov; Vol. 33 (11), pp. 971-978.
DOI:	10.5152/tjg.2022.21834
Abstrakt:	Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization's objective of eliminating viral hepatitis.
Databáze:	MEDLINE
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