Decreased Antibiotic Exposure for Suspected Early-Onset Sepsis in the Neonatal Intensive Care Unit Through Implementation of an Antimicrobial Time-out.
| Autor: | Muller MR; Department of Pharmacy (MRM), Women & Infants Hospital of Rhode Island, Providence, RI.; College of Pharmacy (MRM, PAM), University of Rhode Island, Kingston, RI., Mahadeo AM; Pediatrix Medical Group of Kansas, P.A. (AMM), Kansas City, MO., Mayne JP; Department of Pediatrics (JPM, RT, JMB), Women & Infants Hospital of Rhode Island, Providence, RI.; Warren Alpert Medical School of Brown University (JPM, JMB), Providence, RI., Mennella JM; Icahn School of Medicine at Mount Sinai (JMM), New York, NY., Mun PA; College of Pharmacy (MRM, PAM), University of Rhode Island, Kingston, RI.; Department of Pharmacy (PAM), Kent Hospital, Warwick, RI., Tucker R; Department of Pediatrics (JPM, RT, JMB), Women & Infants Hospital of Rhode Island, Providence, RI., Bliss JM; Department of Pediatrics (JPM, RT, JMB), Women & Infants Hospital of Rhode Island, Providence, RI.; Warren Alpert Medical School of Brown University (JPM, JMB), Providence, RI. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG [J Pediatr Pharmacol Ther] 2022; Vol. 27 (8), pp. 746-749. Date of Electronic Publication: 2022 Nov 17. |
| DOI: | 10.5863/1551-6776-27.8.746 |
| Abstrakt: | Antimicrobials are among the most frequently prescribed drugs in the neonatal intensive care unit (NICU), although most neonates exposed lack a bacterial infection. Overuse of antimicrobials carries risk to the patient and fosters the development of resistant organisms. Strategic and systematic processes hold promise to limit the unnecessary use of these drugs in this population. This study reports a quality improvement initiative in which 2 antimicrobial stewardship strategies were implemented in a large, regional NICU setting: an automatic stop order and an antimicrobial time-out. Antimicrobial use was compared before and after implementation. These 2 simple strategies were associated with a nearly 30% reduction in antibiotic use (31 days per 1000 patient days). Competing Interests: Disclosures. The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria. The authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. (Copyright. Pediatric Pharmacy Association. All rights reserved. For permissions, email membershipo@pediatricpharmacy.org 2022.) |
| Databáze: | MEDLINE |
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