The role of intra-operative parathyroid hormone assay in non-localized adenoma.
| Autor: | M NE; Dr. Noor Ezmas Mahno, MD. Clinical Fellow, Department of Surgery, Clinical Lecturer, Department of Surgery, Kulliyyah of Medicine, International Islamic University Malaysia, Bandar Indera Mahkota Campus, 25200 Kuantan Pahang, Malaysia., Aw N; Dr Norasyikin Abd Wahab, MD. Consultant Endocrinologist, Department of Internal Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, Malaysia., Ml N; Dr Nani Md Latar, MD, PhD. Consultant Breast and Endocrine Surgeon, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, Malaysia. |
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| Jazyk: | angličtina |
| Zdroj: | Pakistan journal of medical sciences [Pak J Med Sci] 2022 Nov-Dec; Vol. 38 (8), pp. 2376-2379. |
| DOI: | 10.12669/pjms.38.8.5688 |
| Abstrakt: | The incidence of primary hyperparathyroidism (PHPT) is increasing in trend due to more common practice of routine blood investigations especially in the elderly. Surgery is the only curative therapy in symptomatic patients. We present a case of a 63-year-old lady with generalised body weakness associated with occasional muscle cramps. Her biochemical results were consistent with PHPT. As a result of persistent severe hypercalcemia, surgery was planned. However, the pre-operative anatomical and functional radiological imaging (neck ultrasonography, 99m Tc-MIBI and FDG-PET scans) failed to identify the abnormal parathyroid gland. Therefore, bilateral neck exploration with intra-operative parathyroid hormone (io-PTH) measurement was performed. The nodular left thyroid and adenomatous right superior parathyroid glands were removed. Possible causes of negative localization and incorporation of io-PTH in under-resourced countries to ensure successful surgery are discussed. Competing Interests: Conflicts of interest: None. (Copyright: © Pakistan Journal of Medical Sciences.) |
| Databáze: | MEDLINE |
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