Emerging role of pericytes in therapy of cardiovascular diseases.

Autor: Dabravolski SA; Department of Biotechnology Engineering, ORT Braude College, Snunit 51, P.O. Box 78, Karmiel 2161002, Israel. Electronic address: sergedobrowolski@gmail.com., Markin AM; Petrovsky National Research Center of Surgery, Abrikosovsky lane, 2, 119991 Moscow, Russia. Electronic address: alexander.markin.34@gmail.com., Andreeva ER; Laboratory of Cell Physiology, Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoye Shosse, 76a, 123007 Moscow, Russia. Electronic address: andreeva1564@gmail.com., Eremin II; Petrovsky National Research Center of Surgery, Abrikosovsky lane, 2, 119991 Moscow, Russia. Electronic address: cd105@mail.ru., Orekhov AN; Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia. Electronic address: a.h.opexob@gmail.com., Melnichenko AA; Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, Moscow 125315, Russia. Electronic address: sasha.melnichenko@gmail.com.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Dec; Vol. 156, pp. 113928. Date of Electronic Publication: 2022 Oct 28.
DOI: 10.1016/j.biopha.2022.113928
Abstrakt: Pericytes are mural vascular cells covering microvascular capillaries, where they contribute to the formation, maturation, maintenance, stabilisation and remodelling of vasculature. They actively interact and communicate with other cells to maintain the capillary structural integrity, vascular permeability and blood flow. Pericytes are crucial participants in the physiological and pathological processes of cardiovascular disease. In this review, we summarise recent data regarding pericyte metabolism, trans-differentiation, angiogenesis and immunomodulation in connection with different cardiovascular pathologies. Further, we discuss an application of pericytes as a new cell therapy approach to treat coronary artery disease, congenital heart disease, atherosclerotic plaques calcification and calcific valvular heart disease in different in vivo animal models and in vitro studies. Also, we discuss different methods and pharmacological therapies for CVDs treatment with pericyte-mediated effects. Finally, we present a comprehensive overview of the role of pericytes in CVDs and as a pharmacological target for different novel drugs and techniques and highlight the potential application of pericytes to treat CVDs.
Competing Interests: Conflict of interest statement The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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