Antioxidant and anti-photoaging effects of a fucoidan isolated from Turbinaria ornata.

Autor: Wang L; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Jayawardena TU; Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of Korea; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada., Hyun J; Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of Korea., Wang K; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Fu X; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Xu J; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Gao X; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Park Y; Department of Family Medicine, Dong-A University Hospital, Daesingongwon-ro, Busan 49201, Republic of Korea. Electronic address: yjpfm@dau.ac.kr., Jeon YJ; Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Republic of Korea. Electronic address: youjin2014@gmail.com.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jan 15; Vol. 225, pp. 1021-1027. Date of Electronic Publication: 2022 Nov 18.
DOI: 10.1016/j.ijbiomac.2022.11.164
Abstrakt: Fucoidans isolated from brown seaweeds are potential ingredients in the cosmetic industry. In our preosvious study, a fucoidan was isolated from the brown seaweed Turbinaria ornata (TO-F10) and the anti-inflammatory effect of TO-F10 was evaluated. In order to further explore the potential of TO-F10 in cosmetics, in the present study, antioxidant and photoprotective effects of TO-F10 were investigated. TO-F10 remarkably protected Vero cells against AAPH-stimulated cell death by reducing apoptosis via scavenging intracellular reactive oxygen species (ROS). In addition, TO-F10 increased the survival rate of AAPH-treated zebrafish by suppressing oxidative stress displayed in reducing the levels of ROS, cell death, and lipid peroxidation. Furthermore, TO-F10 effectively attenuated UVB-induced in vitro and in vivo photodamage. TO-F10 increased the viability of UVB-irradiated human keratinocytes via suppressing apoptosis by reducing the intracellular ROS level. Besides, TO-F10 effectively attenuated in vivo photodamage stimulated by UVB irradiation via inhibiting oxidative stress and inflammatory response in zebrafish. These results demonstrate that TO-F10 possesses in vitro and in vivo antioxidant and photoprotective effects, and suggest TO-F10 is a potential ingredient in the cosmetic industry.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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