Beneficial effects of adding magnesium to desalinated drinking water on metabolic and insulin resistance parameters among patients with type 2 diabetes mellitus: a randomized controlled clinical trial.

Autor: Albaker WI; Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Al-Hariri MT; Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Al Elq AH; Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Alomair NA; Department of Chemistry, Science College, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Alamoudi AS; Desalination Technologies Research Institute, Saline Water Conversation Corporation, Riyadh, Saudi Arabia., Voutchkov N; Desalination Technologies Research Institute, Saline Water Conversation Corporation, Riyadh, Saudi Arabia., Ihm S; Desalination Technologies Research Institute, Saline Water Conversation Corporation, Riyadh, Saudi Arabia., Namazi MA; Desalination Technologies Research Institute, Saline Water Conversation Corporation, Riyadh, Saudi Arabia., Alsayyah AA; Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., AlRubaish FA; Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Alohli FT; Department of Family Medicine, Armed Forces Hospital, Dhahran, Eastern Province Saudi Arabia., Zainuddin FA; Department of Medical Allied Services, Imam Abdulrahman Bin Faisal University -King Fahd Hospital of the University Eastern Province, Dammam, Saudi Arabia., Alobaidi AA; Department of Medical Allied Services, Imam Abdulrahman Bin Faisal University -King Fahd Hospital of the University Eastern Province, Dammam, Saudi Arabia., Almuzain FA; Department of Medical Allied Services, Imam Abdulrahman Bin Faisal University -King Fahd Hospital of the University Eastern Province, Dammam, Saudi Arabia., Elamin MO; Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Alamoudi NB; Intern, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Alamer MA; Intern, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., Alghamdi AA; Intern, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia., AlRubaish NA; Intern, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province Saudi Arabia.
Jazyk: angličtina
Zdroj: NPJ clean water [NPJ Clean Water] 2022; Vol. 5 (1), pp. 63. Date of Electronic Publication: 2022 Nov 12.
DOI: 10.1038/s41545-022-00207-9
Abstrakt: There is evidence that increasing the consumption of water containing magnesium can improve glucose metabolism and insulin resistance in patients with type 2 diabetes mellitus (T2DM). This trial was undertaken with the objective of evaluating the effect of adding different concentrations of magnesium chloride to the desalinated drinking water on the glycemic, metabolic, and insulin resistance parameters among patients with T2DM. A randomized cross-sectional controlled clinical trial was conducted to evaluate the effects of adding magnesium chloride supplement to desalinated drinking water consumed by patients with T2DM on the glycemic and metabolic parameters and indicators of insulin sensitivity. The total number of patients with T2DM who successfully completed the trial is 102. Patients were randomly allocated into three groups: the first group received bottled water without added magnesium (0 mg/L) (Group A, n  = 37); the second group received bottled water with a low level of magnesium (20 mg/L) (Group B, n  = 33); and the third group received drinking water with a high level of magnesium (50 mg/L) (Group C, n  = 32). The daily consumption of elemental magnesium for a period of 3 months resulted in significant improvement in HbA1C (8.0 vs 8.2%, p  = 0.04), insulin level (7.5 vs 9.9 μIU/mL, p  = 0.03), and homeostasis model assessment-estimated insulin resistance (HOMA.IR) (2.5 vs 2.9, p  = 0.002) in group C. However, there was no significant improvement in fasting blood glucose (FBS) level or lipid profile. The results of this study suggest that oral magnesium supplementation at the given dose of 50 mg/L daily added to drinking water could improve long-term glycemic control indicators and reduce insulin resistance in patients with T2DM.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© The Author(s) 2022.)
Databáze: MEDLINE
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