Biocatalyst developed with recovered iron-rich minerals enhances the biotransformation of SARS-CoV-2 antiviral drugs in anaerobic bioreactors.

Autor: Mares-Carbajal FJ; Laboratory for Research on Advanced Processes for Water Treatment, Engineering Institute, Campus Juriquilla, Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3001, 76230 Querétaro, Mexico., Espinosa-Arzate MC; Laboratory for Research on Advanced Processes for Water Treatment, Engineering Institute, Campus Juriquilla, Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3001, 76230 Querétaro, Mexico., Ramírez-Montoya LA; Laboratory for Research on Advanced Processes for Water Treatment, Engineering Institute, Campus Juriquilla, Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3001, 76230 Querétaro, Mexico., Pat-Espadas AM; CONACYT-UNAM Instituto de Geología, Estación Regional del Noroeste (ERNO), Luis D. Colosio y Madrid, Hermosillo, Sonora, Mexico., Ramírez JE; Unidad Académica de Ingeniería I, Universidad Autónoma de Zacatecas, Zacatecas, Mexico., Rangel-Mendez JR; División de Ciencias Ambientales, Instituto Potosino de Investigación Científica y Tecnológica, Camino a la Presa San José 2055, Lomas 4 Sección, 78216 San Luis Potosí, Mexico., Ascacio-Valdes JA; Facultad de Ciencias Químicas, Departamento de Investigación en Alimentos (DIA-UAdeC), Universidad Autónoma de Coahuila, Saltillo 25280, Coahuila, Mexico., Aguilar CN; Facultad de Ciencias Químicas, Departamento de Investigación en Alimentos (DIA-UAdeC), Universidad Autónoma de Coahuila, Saltillo 25280, Coahuila, Mexico., Mijaylova P; Subcoordinación de Tratamiento de Aguas Residuales, Instituto Mexicano de Tecnología del Agua, Paseo Cuauhnáhuac 8532, Progreso, Jiutepec 62550, Morelos, Mexico., Buitrón G; Laboratory for Research on Advanced Processes for Water Treatment, Engineering Institute, Campus Juriquilla, Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3001, 76230 Querétaro, Mexico., Cervantes FJ; Laboratory for Research on Advanced Processes for Water Treatment, Engineering Institute, Campus Juriquilla, Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3001, 76230 Querétaro, Mexico.
Jazyk: angličtina
Zdroj: Journal of water process engineering [J Water Process Eng] 2022 Dec; Vol. 50, pp. 103337. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1016/j.jwpe.2022.103337
Abstrakt: The biotransformation of the SARS-CoV-2 antiviral drugs, ribavirin and tenofovir, was studied in methanogenic bioreactors. The role of iron-rich minerals, recovered from a metallurgic effluent, on the biotransformation process was also assessed. Enrichment of anaerobic sludge with recovered minerals promoted superior removal efficiency for both antivirals (97.4 % and 94.7 % for ribavirin and tenofovir, respectively) as compared to the control bioreactor lacking minerals, which achieved 58.5 % and 37.9 % removal for the same drugs, respectively. Further analysis conducted by liquid chromatography coupled to mass spectroscopy revealed several metabolites derived from the biotransformation of both antivirals. Interestingly, tracer analysis with 13 CH 4 revealed that anaerobic methane oxidation coupled to Fe(III) reduction occurred in the enriched bioreactor, which was reflected in a lower content of methane in the biogas produced from this system, as compared to the control bioreactor. This treatment proposal is suitable within the circular economy concept, in which recovered metals from an industrial wastewater are applied in bioreactors to create a biocatalyst for promoting the biotransformation of emerging pollutants. This strategy may be appropriate for the anaerobic treatment of wastewaters originated from hospitals, as well as from the pharmaceutical and chemical sectors.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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