F-18 Fluciclovine PET-CT Findings and Pseudoprogression on Immunotherapy.
| Autor: | Poindexter BC; Radiology, Burrell College of Osteopathic Medicine, Las Cruces, USA., Kasireddy NM; Radiology, Dartmouth College, Hanover, USA., Molchanova-Cook OP; Radiology, Memorial Medical Center, Las Cruces, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Oct 17; Vol. 14 (10), pp. e30380. Date of Electronic Publication: 2022 Oct 17 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.30380 |
| Abstrakt: | Immunotherapy plays a vital role in the treatment of several types of malignancies. While the molecular targets of immunotherapy differ, the desired goal is to increase the host immune response against neoplastic tissue. This upregulated immune state results in infiltration of the tumor with activated immune cells and may be misinterpreted as disease progression in anatomical and metabolic imaging studies, known as pseudoprogression. We present a case of pseudoprogression demonstrated on a fluoride-18 (F-18) fluciclovine positron emission tomography-computed tomography (PET-CT) scan of an 85-year-old male with metastatic castrate-resistant prostate cancer who underwent treatment with sipuleucel-T. An understanding of the pseudoprogression phenomenon and its manifestations is critical for both treating physicians and imaging specialists to facilitate decision-making regarding treatment. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Poindexter et al.) |
| Databáze: | MEDLINE |
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