Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60-70 years) with oxidative etiology diseases.

Autor:	León Fernández OS; Pharmacy and Food Institute, University of Havana, Havana, Cuba., Oru GT; Pharmacy and Food Institute, University of Havana, Havana, Cuba., Viebahn-Hänsler R; Medical Society for the Use of Ozone in Prevention and Therapy, Iffezheim/Baden- Baden, Germany., López Cabreja G; National Institute of Rheumatology, Ministry of Public Health, Havana, Cuba., Serrano Espinosa I; National Institute of Rheumatology, Ministry of Public Health, Havana, Cuba., García Fernández E; Pharmacy and Food Institute, University of Havana, Havana, Cuba.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2022 Nov 03; Vol. 13, pp. 1029805. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).
DOI:	10.3389/fphys.2022.1029805
Abstrakt:	Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60-70 years) rheumatoid arthritis patients with diabetes and hypertension, as well as another group with bronchial asthma patients in order to demonstrate the beneficial effects of medical ozone in the prevention and therapy of age-related diseases in these age groups. A randomized clinical study with 45 older patients (60-70 years) was performed. Group I (n = 15) with rheumatoid arthritis + diabetes and hypertension received no ozone treatment, and group II (n = 30) was treated with medical ozone. This group was divided into two subgroups (n = 15 each), group IIa: the same as group I + medical ozone and group IIb: bronchial asthma patients. Indicators of RA in I and IIa groups were evaluated. Redox balance was assessed through defense and injury biomarkers. Thromboxane A2 (TXA2) and prostacyclin levels were assessed in group IIb patients. Medical ozone arrested oxidative injury progression in the Ia group and decreased thromboxane levels and the TXA2/6-keto PGF1α ratio in the IIb group. Medical ozone arrested the progression of oxidative damage and modulated those endogenous mechanisms that promote a suitable redox status and TXA2/PGI2 balance. These results suggest that medical ozone may become a standard approach in the prevention and management of age-related oxidative diseases in elderly people. (Copyright © 2022 León Fernández, Oru, Viebahn-Hänsler, López Cabreja, Serrano Espinosa and García Fernández.)
Databáze:	MEDLINE
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