The HMOX2 polymorphism contributes to the carotid body chemoreflex in European sea-level residents by regulating hypoxic ventilatory responses.
| Autor: | Fabries P; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; French Military Health Academy - Ecole du Val-de-Grâce, Paris, France.; Laboratoire de Biologie de l'Exercice pour la Performance et la Santé - LBEPS - UMR, Université Paris-Saclay, IRBA, Evry-Courcouronnes, France., Drogou C; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; Vigilance Fatigue Sommeil et Santé Publique - VIFASOM - UPR 7330, Université de Paris Cité, Paris, France., Sauvet F; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; French Military Health Academy - Ecole du Val-de-Grâce, Paris, France.; Vigilance Fatigue Sommeil et Santé Publique - VIFASOM - UPR 7330, Université de Paris Cité, Paris, France., Nespoulous O; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France., Erkel MC; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; Vigilance Fatigue Sommeil et Santé Publique - VIFASOM - UPR 7330, Université de Paris Cité, Paris, France., Marchandot V; 41ème Antenne médicale, 5ème Centre médical des Armées, Dieuze, France., Bouaziz W; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France., Lepetit B; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; Laboratoire de Biologie de l'Exercice pour la Performance et la Santé - LBEPS - UMR, Université Paris-Saclay, IRBA, Evry-Courcouronnes, France., Hamm-Hornez AP; Aeromedical Center - CPEMPN - Percy Military Hospital, Clamart, France., Malgoyre A; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; Laboratoire de Biologie de l'Exercice pour la Performance et la Santé - LBEPS - UMR, Université Paris-Saclay, IRBA, Evry-Courcouronnes, France., Koulmann N; French Military Health Academy - Ecole du Val-de-Grâce, Paris, France.; Laboratoire de Biologie de l'Exercice pour la Performance et la Santé - LBEPS - UMR, Université Paris-Saclay, IRBA, Evry-Courcouronnes, France., Gomez-Merino D; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; Vigilance Fatigue Sommeil et Santé Publique - VIFASOM - UPR 7330, Université de Paris Cité, Paris, France., Chennaoui M; French Armed Forces Biomedical Research Institute - IRBA, Brétigny-sur-Orge, France.; Vigilance Fatigue Sommeil et Santé Publique - VIFASOM - UPR 7330, Université de Paris Cité, Paris, France. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in medicine [Front Med (Lausanne)] 2022 Nov 03; Vol. 9, pp. 1000786. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022). |
| DOI: | 10.3389/fmed.2022.1000786 |
| Abstrakt: | This study investigates whether a functional single nucleotide polymorphism of HMOX2 (heme oxygenase-2) (rs4786504 T>C) is involved in individual chemosensitivity to acute hypoxia, as assessed by ventilatory responses, in European individuals. These responses were obtained at rest and during submaximal exercise, using a standardized and validated protocol for exposure to acute normobaric hypoxia. Carriers of the ancestral T allele ( n = 44) have significantly lower resting and exercise hypoxic ventilatory responses than C/C homozygous carriers ( n = 40). In the literature, a hypoxic ventilatory response threshold to exercise has been identified as an independent predictor of severe high altitude-illness (SHAI). Our study shows that carriers of the T allele have a higher risk of SHAI than carriers of the mutated C/C genotype. Secondarily, we were also interested in COMT (rs4680 G > A) polymorphism, which may be indirectly involved in the chemoreflex response through modulation of autonomic nervous system activity. Significant differences are present between COMT genotypes for oxygen saturation and ventilatory responses to hypoxia at rest. In conclusion, this study adds information on genetic factors involved in individual vulnerability to acute hypoxia and supports the critical role of the ≪ O Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Fabries, Drogou, Sauvet, Nespoulous, Erkel, Marchandot, Bouaziz, Lepetit, Hamm-Hornez, Malgoyre, Koulmann, Gomez-Merino and Chennaoui.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|