Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells.

Autor: Tsai PW; Department of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan., Tayo LL; School of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, 1002 Metro Manila, the Philippines., Ting JU; Department of Chemistry, College of Science, De La Salle University, Metro Manila 1004, the Philippines., Hsieh CY; Ph.D. Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan., Lee CJ; Ph.D. Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan., Chen CL; Department of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan., Yang HC; Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan., Tsai HY; Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan., Hsueh CC; Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan., Chen BY; Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan.
Jazyk: angličtina
Zdroj: Industrial crops and products [Ind Crops Prod] 2023 Jan; Vol. 191, pp. 115944. Date of Electronic Publication: 2022 Nov 10.
DOI: 10.1016/j.indcrop.2022.115944
Abstrakt: Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (-6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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