Chewing Gum for Prevention of Nausea and Vomiting After Elective Caesarean Section: a Pilot Randomised Controlled Trial.

Autor: Bowe R; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., Irwin R; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., Browne G; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., Harbison M; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., Gallen S; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., Yore PJ; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., MacGearailt E; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., Popivanov P; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland., Tan T; Department of Anaesthesia, The Coombe Women and Infants University Hospital, Dublin, Ireland.
Jazyk: angličtina
Zdroj: SN comprehensive clinical medicine [SN Compr Clin Med] 2022; Vol. 4 (1), pp. 257. Date of Electronic Publication: 2022 Nov 14.
DOI: 10.1007/s42399-022-01332-9
Abstrakt: Nausea and vomiting are common complications in patients undergoing caesarean delivery under regional anaesthesia. When experienced after surgery, they may delay recovery, reduce patient satisfaction and affect the bonding between mother and baby. Various pharmacological and non-pharmacological approaches for prophylaxis and treatment of postoperative nausea and vomiting (PONV) have been employed with different degree of efficacy. In this pilot randomised controlled trial, we aimed to determine the possible preventative effects of chewing gum on the rate of PONV in expectant mothers undergoing neuraxial anaesthesia for elective lower segment caesarean section. All participants underwent spinal anaesthesia with administration of 10-11.5 mg of intrathecal heavy Bupivicaine 0.5% according to anaesthetists' preference, Morphine 100 μg and Fentanyl 25 μg. Postoperative analgesia regimen was also standardised. Two hundred ninety-six patients were randomised to an intervention arm to receive chewing gum in addition to standard therapy and to a non-intervention arm to receive standard therapy. After exclusions, 258 patients were followed up 24 h postoperatively. Standard therapy is defined as Ondansetron 4 mg IV intra-operatively. The primary outcomes were the incidences of nausea and vomiting in the first 24 h postoperatively. Secondary outcomes were the number of episodes of nausea or vomiting in the recovery room and on the ward 24 h postoperatively, use of anti-emetics postoperatively, severity of nausea and patient satisfaction with the intervention. Our study revealed no significant differences in rates of postoperative nausea and vomiting between the intervention and standard therapy groups (41.4% v 36.9% p  = 0.461). There were no significant differences in secondary outcomes between groups. Chewing gum does not reduce the incidence of PONV after elective LSCS under spinal anaesthesia. Our trial was registered with clinicaltrials.org (NCT04191694).
Competing Interests: Conflict of InterestThe authors declare no competing interests.
(© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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