Camel milk ameliorates diabetes in pigs by preventing oxidative stress, inflammation and enhancing beta cell function.

Autor: Rilwan HB; Department of Human Anatomy, Kaduna State University, Kaduna, Kaduna State Nigeria., Adebisi SS; Department of Human Anatomy, Ahmadu Bello University, Zaria, Kaduna State Nigeria., Timbuak JA; Department of Human Anatomy, Yusuf Maitama Sule University, Kano, Kano State Nigeria., Oladele SB; Department of Veterinary Anatomy, Ahmadu Bello University, Zaria, Kaduna State Nigeria., Muhammad A; Department of Human Physiology, Ahmadu Bello University, Zaria, Kaduna State Nigeria., Sadeeq AA; Department of Human Anatomy, Ahmadu Bello University, Zaria, Kaduna State Nigeria., Makena W; Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Maiduguri, Maiduguri, Borno State Nigeria.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2022 Sep 16; Vol. 21 (2), pp. 1625-1634. Date of Electronic Publication: 2022 Sep 16 (Print Publication: 2022).
DOI: 10.1007/s40200-022-01112-1
Abstrakt: Purpose: The purpose of the study was to determine how camel milk affects hyperglycemia, beta-cell function, oxidative stress, and inflammatory markers in type 2 diabetic pigs.
Methods: Twenty-five (25) pigs were separated into five (5) groups of five pigs each, with five (5) non-diabetic and twenty (20) diabetic pigs in each group. Groups 1 and 2 received distilled water as the standard control and diabetic control groups, respectively, while Groups 3 and 4 received camel milk at 250 mL/day and 500 mL/day, respectively, and Group 5 received metformin at 500 mg/day. The experiment lasted ten weeks. At the end of the ten weeks, all the pigs were euthanized.
Results: Treatments with camel milk substantially enhance glucose fasting levels by reducing hyperglycemia in diabetic pigs, significant level at (p < 0.05). When pigs given camel milk were compared with untreated diabetic pigs, there was a substantial rise (p < 0.05) in superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels. Also, camel milk substantially lowered the levels of interleukin (IL-1β) and tumour necrosis factor-alpha (TNF-α) in diabetic pig serum. Similarly, immunohistochemical analysis of islet cells revealed an increase in insulin production, implying improved glycemic control and the eventual commitment of glucose to glycolysis.
Conclusion: The bioactive-mediated anti-hyperglycemic and insulin release potential of camel milk treatments contributed to improving type 2 diabetes mellitus. Camel milk improved beta-cell function while reducing oxidative stress and inflammation in type 2 diabetic pigs.
Competing Interests: Competing interestsThe authors declare there are no competing interests.
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Databáze: MEDLINE
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