Comparison of SARS-CoV-2 viral load in asymptomatic and symptomatic children attended in a referral public pediatric hospital in Argentina.

Autor:	Golemba MD; Unidad de Virología y Epidemiología Molecular - CONICET, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: mgolemba@garrahan.gov.ar., Moragas M; Unidad de Virología y Epidemiología Molecular - CONICET, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Fernández MF; Unidad de Virología y Epidemiología Molecular - CONICET, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Borgnia D; Unidad de Virología y Epidemiología Molecular - CONICET, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Ruhle M; Unidad de Virología y Epidemiología Molecular - CONICET, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Palladino M; Unidad de Cuidados Intermedios y Moderados, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Arias AP; Servicio de Epidemiología e Infectología, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Ruvinsky S; Coordinación de Investigación, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Bologna R; Servicio de Epidemiología e Infectología, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina., Mangano A; Unidad de Virología y Epidemiología Molecular - CONICET, Hospital de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad Autónoma de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
Jazyk:	angličtina
Zdroj:	Revista Argentina de microbiologia [Rev Argent Microbiol] 2023 Apr-Jun; Vol. 55 (2), pp. 143-149. Date of Electronic Publication: 2022 Oct 31.
DOI:	10.1016/j.ram.2022.09.002
Abstrakt:	At present, different reports have shown that children reach similar SARS-CoV-2 viral load (VL) levels compared to adults; however, the impact of VL on children remains ambiguous when asymptomatic versus symptomatic cases are compared. Thus, the aim of this study was to assess VL at the time of diagnosis in asymptomatic and symptomatic SARS-CoV-2 infected children. VL analysis was retrospectively carried out from nasopharyngeal swabs on 82 SARS-CoV-2 infected children, from March to October 2020. Of the 82 children, 31 were asymptomatic. Symptomatic patients had significantly higher VL values compared to asymptomatic ones (median=7.41 vs 4.35log10 copies/ml, respectively). Notwithstanding, 8 out of 31 asymptomatic children had high VL levels, overlapping levels observed above the first quartile in the symptomatic group. Analysis of different age groups revealed that median VL values were higher in the symptomatic groups, although there was only a significant difference in children younger than 5 years of age. On the other hand, there was no significant difference between the VL values from the 82 SARS-CoV-2 infected children according to age, sex, underlying disease, symptoms or severity of COVID-19 related disease. This study emphasizes the importance of VL analysis in SARS-CoV-2 infected children, who could contribute to viral spread in the community. This concern could be extended to healthcare workers, who are in contact with children. (Copyright © 2022 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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