Impact of diabetes status and related factors on COVID-19-associated hospitalization: A nationwide retrospective cohort study of 116,370 adults with SARS-CoV-2 infection.

Autor: Tallon EM; Institute for Data Science and Informatics, University of Missouri, 22 Heinkel Building, Columbia, MO 65211, USA. Electronic address: erin.tallon@mail.missouri.edu., Ebekozien O; T1D Exchange, 11 Avenue de Lafayette, Boston, MA 02111, USA; School of Population Health, University of Mississippi, 2500 North State Street, Jackson, MS 39216, USA., Sanchez J; University of Miami, 1601 NW 12th Avenue, Miami, FL 33136, USA., Staggs VS; Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA; School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA., Ferro D; Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA; School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA., McDonough R; Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA; School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA., Demeterco-Berggren C; Rady Children's Hospital, San Diego, 3030 Children's Way, San Diego, CA 92123, USA., Polsky S; Barbara Davis Center for Diabetes, Adult Clinic, University of Colorado Anschutz Medical Campus, 1775 Aurora Court, MS A140, Aurora, CO 80045, USA., Gomez P; University of Miami, 1601 NW 12th Avenue, Miami, FL 33136, USA., Patel N; Penn State Health Children's Hospital, 12 Briarcrest Square, Hershey, PA 17033, USA., Prahalad P; Stanford University, 730 Welch Road, Palo Alto, CA 94304, USA., Odugbesan O; T1D Exchange, 11 Avenue de Lafayette, Boston, MA 02111, USA., Mathias P; Albert Einstein College of Medicine, Montefiore Medical Center, 1800 Morris Park Avenue, Bronx, NY 10461, USA., Lee JM; University of Michigan, Pediatric Endocrinology, Susan B. Meister Child Health Evaluation and Research Center, 2800 Plymouth Rd NCRC Building 16, Ann Arbor, MI 48109-2800, USA., Smith C; Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA., Shyu CR; Institute for Data Science and Informatics, University of Missouri, 22 Heinkel Building, Columbia, MO 65211, USA; Department of Electrical Engineering and Computer Science, University of Missouri, 201 Naka Hall, Columbia, MO 65211, USA; School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO 65212, USA., Clements MA; Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA; School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA.
Jazyk: angličtina
Zdroj: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2022 Dec; Vol. 194, pp. 110156. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1016/j.diabres.2022.110156
Abstrakt: Aims: We examined diabetes status (no diabetes; type 1 diabetes [T1D]; type 2 diabetes [T2D]) and other demographic and clinical factors as correlates of coronavirus disease 2019 (COVID-19)-related hospitalization. Further, we evaluated predictors of COVID-19-related hospitalization in T1D and T2D.
Methods: We analyzed electronic health record data from the de-identified COVID-19 database (December 2019 through mid-September 2020; 87 US health systems). Logistic mixed models were used to examine predictors of hospitalization at index encounters associated with confirmed SARS-CoV-2 infection.
Results: In 116,370 adults (>=18 years old) with COVID-19 (93,098 no diabetes; 802 T1D; 22,470 T2D), factors that independently increased risk for hospitalization included diabetes, male sex, public health insurance, decreased body mass index (BMI; <25.0-29.9 kg/m 2 ), increased BMI (>25.0-29.9 kg/m 2 ), vitamin D deficiency/insufficiency, and Elixhauser comorbidity score. After further adjustment for concurrent hyperglycemia and acidosis in those with diabetes, hospitalization risk was substantially higher in T1D than T2D and in those with low vitamin D and elevated hemoglobin A1c (HbA1c).
Conclusions: The higher hospitalization risk in T1D versus T2D warrants further investigation. Modifiable risk factors such as vitamin D deficiency/insufficiency, BMI, and elevated HbA1c may serve as prognostic indicators for COVID-19-related hospitalization in adults with diabetes.
Competing Interests: Declaration of Competing Interest MAC is the Chief Medical Officer at Glooko. He receives research support from Dexcom and Abbott Diabetes Care. NP receives research grant support from Dexcom through an investigator-initiated study. SP has been a contributing editor for diaTribe and has served on a medical advisory board for Medtronic MiniMed, Inc. Through the University of Colorado, she has received research funding from Dexcom, Inc., Eli Lilly, JDRF, the Leona M. & Harry B. Helmsley Charitable Trust, the National Institutes of Health, and Sanofi US Services. JML serves on a medical advisory board for GoodRx and serves as a consultant for Tandem Diabetes Care. No other potential conflicts of interest relevant to this article were reported.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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