Incident Early- and Later-Onset Type 2 Diabetes and Risk of Early- and Later-Onset Cancer: Prospective Cohort Study.

Autor:	Zhang Y; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA., Song M; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Cao Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO.; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO., Eliassen AH; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Stampfer MJ; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Willett WC; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA., Wu K; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA., Ng K; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Hu FB; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Giovannucci EL; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Jazyk:	angličtina
Zdroj:	Diabetes care [Diabetes Care] 2023 Jan 01; Vol. 46 (1), pp. 120-129.
DOI:	10.2337/dc22-1575
Abstrakt:	Objective: We evaluated prospectively the association between incident early-onset (diagnosed before 40 years of age) and later-onset type 2 diabetes and early-onset (diagnosed before 50 years of age) and later-onset cancer risk. Research Design and Methods: We prospectively followed 228,073 eligible participants in the Nurses' Health Studies for up to 38 years. Hazard ratios (HRs) and 95% CI were estimated using Cox models. Results: We documented 18,290 type 2 diabetes, 6,520 early-onset cancer, and 36,907 later-onset cancer cases during follow-up. In fully adjusted analyses, early-onset type 2 diabetes was associated with increased risk of early-onset total cancer (HR [95% CI] 1.47 [1.06-2.04]), diabetes-related cancer (2.11 [1.38-3.23]), and obesity-related cancer (1.75 [1.08-2.82]), and the risk elevations were restricted to those with a BMI at 18 years of age of ≥21 kg/m2 (total cancer: 1.75 [1.20-2.56]; diabetes-related cancer: 2.43 [1.50-3.94]; and obesity-related cancer: 1.84 [1.05-3.22]). Early-onset type 2 diabetes was associated with higher risk of later-onset diabetes-related and obesity-related cancer specifically among individuals with higher BMI at 18 years of age. Later-onset type 2 diabetes was associated with a higher risk of later-onset total cancer (1.15 [1.11-1.20]), diabetes-related cancer (1.17 [1.12-1.22]), and obesity-related cancer (1.18 [1.13-1.24]). In analyses based on refined timing, the HRs attenuated substantially with aging. Conclusions: Incident early-onset type 2 diabetes was associated with increased risk of early-onset total cancer and diabetes- and obesity-related cancer, especially in those with higher BMI at 18 years of age. The impact of early-onset type 2 diabetes on cancer risk may be inherently stronger than that of later-onset type 2 diabetes. (© 2022 by the American Diabetes Association.)
Databáze:	MEDLINE
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