Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature.

Autor: Kaagaard MD; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil.; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark., Wegener A; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil.; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark., Gomes LC; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Holm AE; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil.; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark., Lima KO; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil., Matos LO; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil., Vieira IVM; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil., de Souza RM; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil., Vestergaard LS; National Malaria Reference Laboratory, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark., Marinho CRF; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Dos Santos FB; Laboratório de Imunologia Viral, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil., Biering-Sørensen T; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.; Faculty of Biomedical Sciences, Copenhagen University, Copenhagen, Denmark., Silvestre OM; Health and Sport Science Center, Federal University of Acre, Rio Branco, Acre, Brazil., Brainin P; Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Acre, Brazil.; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Nov 18; Vol. 17 (11), pp. e0276725. Date of Electronic Publication: 2022 Nov 18 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0276725
Abstrakt: Background: Dengue virus can affect the cardiovascular system and men may be at higher risk of severe complications than women. We hypothesized that clinical dengue virus (DENV) infection could induce myocardial alterations of the left ventricle (LV) and that these changes could be detected by transthoracic echocardiography.
Methodology/principal Findings: We examined individuals from Acre in the Amazon Basin of Brazil in 2020 as part of the Malaria Heart Study. By questionnaires we collected information on self-reported prior dengue infection. All individuals underwent transthoracic echocardiography, analysis of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). We included 521 persons (mean age 40±15 years, 39% men, 50% urban areas) of which 253 (49%) had a history of dengue infection. In multivariable models adjusted for clinical and sociodemographic data, a history of self-reported dengue was significantly associated with lower LVEF (β = -2.37, P < 0.01) and lower GLS (β = 1.08, P < 0.01) in men, whereas no significant associations were found in women (P > 0.05). In line with these findings, men with a history of dengue had higher rates of LV systolic dysfunction (LVEF < 50% = 20%; GLS < 16% = 17%) than those without a history of dengue (LVEF < 50% = 7%; GLS < 16% = 8%; P < 0.01 and 0.06, respectively).
Conclusions/significance: The findings of this study suggest that a clinical infection by dengue virus could induce myocardial alterations, mainly in men and in the LV, which could be detected by conventional transthoracic echocardiography. Hence, these results highlight a potential role of echocardiography for screening LV dysfunction in participants with a history of dengue infection. Further larger studies are warranted to validate the findings of this study.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2022 Kaagaard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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