The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study.

Autor:	Yamanashi T; Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94305, USA.; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA.; Tottori University Faculty of Medicine, Department of Neuropsychiatry, Yonago-Shi, Tottori, Japan., Anderson ZE; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Modukuri M; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Chang G; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Tran T; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Marra PS; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Wahba NE; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Crutchley KJ; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Sullivan EJ; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Jellison SS; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Comp KR; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Akers CC; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Meyer AA; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA., Lee S; University of Iowa Carver College of Medicine, Department of Emergency Medicine, Iowa City, IA 52242, USA., Iwata M; Tottori University Faculty of Medicine, Department of Neuropsychiatry, Yonago-Shi, Tottori, Japan., Cho HR; University of Iowa College of Public Health, Department of Biostatistics, Iowa City, IA 52242, USA., Shinozaki E; University of Iowa Carver College of Medicine, Department of Internal Medicine, Iowa City, IA 52242, USA., Shinozaki G; Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94305, USA.; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA.
Jazyk:	angličtina
Zdroj:	Aging [Aging (Albany NY)] 2022 Nov 17; Vol. 14 (22), pp. 8927-8943. Date of Electronic Publication: 2022 Nov 17.
DOI:	10.18632/aging.204393
Abstrakt:	Purpose: Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality. Methods: In this retrospective cohort study, previously recruited 1,404 subjects were analyzed. The relationship between metformin use and delirium, and the relationship between metformin use and 3-year mortality were investigated. Main Findings: 242 subjects were categorized into a type 2 diabetes mellitus (DM)-without-metformin group, and 264 subjects were categorized into a DM-with-metformin group. Prevalence of delirium was 36.0% in the DM-without-metformin group, and 29.2% in the DM-with-metformin group. A history of metformin use reduced the risk of delirium in patients with DM (OR, 0.50 [95% CI, 0.32 to 0.79]) after controlling for confounding factors. The 3-year mortality in the DM-without-metformin group (survival rate, 0.595 [95% CI, 0.512 to 0.669]) was higher than in the DM-with-metformin group (survival rate, 0.695 [95% CI, 0.604 to 0.770]) (p=0.035). A history of metformin use decreased the risk of 3-year mortality after adjustment for confounding factors (HR, 0.69 [95% CI, 0.48 to 0.98]). Conclusions: Metformin use may lower the risk of delirium and mortality in DM patients.
Databáze:	MEDLINE
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