The management of retroperitoneal sarcoma: The experience of a single institution and a review of the literature.
| Autor: | Feki J; Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Tunisia., Lajnef M; Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Tunisia., Fourati M; Department of Urology, Habib Bourguiba Hospital, University of Sfax, Tunisia., Sakka D; Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Tunisia., Hassena RB; Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Tunisia., Slimen MH; Department of Urology, Habib Bourguiba Hospital, University of Sfax, Tunisia., Daoud J; Department of Radiotherapy, Habib Bourguiba Hospital, University of Sfax, Tunisia., Khanfir A; Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Tunisia. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of Taibah University Medical Sciences [J Taibah Univ Med Sci] 2022 Aug 18; Vol. 18 (1), pp. 125-131. Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2023). |
| DOI: | 10.1016/j.jtumed.2022.07.007 |
| Abstrakt: | Objectives: Retroperitoneal sarcomas (RPSs) are rare mesenchymal tumors. The objective of this study was to discuss the different clinical, therapeutic and prognostic aspects of RPS in our institution. Methods: This was a retrospective study conducted at the Department of Medical Oncology in the Habib Bourguiba University Hospital in Sfax, including 19 patients who were treated for RPSs between 1999 and 2016. Results: The median age was 49 years (range: 18-83 years); 68.4% of the patients were female. The commonest symptom was abdominal pain (88%) and the median tumor size was 15 cm (range: 4-30 cm). Complete resection was achieved in only five cases (26.3%). The most common histological subtypes were liposarcoma (47.4%) and leiomyosarcoma (26.3%). Eight patients had a high-grade tumor (G2 = 2 or G3 = 6). Adjuvant radiotherapy was administered in 5 patients (26%). Seventeen patients were treated with chemotherapy; six received chemotherapy in an adjuvant treatment, three as a neoadjuvant treatment, and eight were treated during the palliative phase. Relapse was observed in 58% of cases. For all patients, the overall survival (OS) was 89.5% at 1 year and 40.3% at 5 years. Prognostic factors influencing OS were sex ( p = 0.037), resection margins ( p = 0.02), recurrence ( p = 0.042), and radiotherapy ( p = 0.023). In multivariate analysis, radiotherapy ( p = 0.031) and histological subtype ( p = 0.028) were independent factors influencing OS and disease-free survival (DFS) respectively. Conclusion: We showed that the treatment of RPSs relies on surgery with complete resection. Other factors, such as radiotherapy and the occurrence of relapse, also have an impact on OS. To facilitate surgery and to obtain negative resection margins, preoperative radiotherapy is indicated in selected patients with a high risk of relapse. Further prospective trials are warranted to select optimal therapies with less toxicity and better efficacy in reducing recurrences, mainly at a local level. (© 2022 [The Author/The Authors].) |
| Databáze: | MEDLINE |
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